News tagged with metabolic pathways

Cancer suppressor gene links metabolism with cellular aging

The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...

Jan 13, 2013
popularity 3.7 / 5 (3) | comments 0 | with audio podcast

Targeting cancer's sweet tooth

Ludwig researchers have elucidated a key mechanism by which cancer cells change how they metabolize glucose to generate the energy and raw materials required to sustain runaway growth.

Oct 21, 2013
popularity 5 / 5 (2) | comments 0 | with audio podcast

Hijacking stress response in cancer

(Medical Xpress)—Cancer cells have alteration in metabolic pathways as a result of oncogenes that promote tumor growth. NRF2 (nuclear factor erythroid-derived 2-related factor 2) works as a "master gene" that turns on stress ...

Jul 02, 2013
popularity 5 / 5 (1) | comments 0 | with audio podcast