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News tagged with metastasis

Changing cancer's environment to halt its spread

By studying the roles two proteins, thrombospondin-1 and prosaposin, play in discouraging cancer metastasis, a trans-Atlantic research team has identified a five-amino acid fragment of prosaposin that significantly reduces ...

Cancer created 22 hours ago | popularity 5 / 5 (1) | comments 0

Risk factors ID'd for poor cutaneous cell CA outcomes

(HealthDay)—The risks of metastasis and death associated with cutaneous squamous cell carcinoma (CSCC) are low, but significant, and risk factors for poor outcome include tumor diameter, invasion beyond ...

Cancer created May 17, 2013 | popularity not rated yet | comments 0 | with audio podcast

Tumor-activated protein promotes cancer spread

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system – a network of vessels that transports and ...

Cancer created May 13, 2013 | popularity 4.2 / 5 (5) | comments 0 | with audio podcast

Decoded: Molecular messages that tell prostate and breast cancers to spread

Cancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain ...

Cancer created Apr 30, 2013 | popularity not rated yet | comments 0 | with audio podcast

Battery of tests on cancer cells shows them as 'squishy,' yet tactically strong

A team of student researchers and their professors from 20 laboratories around the country have gotten a new view of cancer cells. The work could shed light on the transforming physical properties of these cells as they metastasize, ...

Cancer created Apr 26, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Metastasis stem cells in the blood of breast cancer patients discovered

Individual cancer cells that break away from the original tumor and circulate through the blood stream are considered responsible for the development of metastases. These dreaded secondary tumors are the ...

Cancer created Apr 22, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Study finds new drug target for metastatic breast cancer

Research led by Dr. Suresh Alahari, Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, is the first to report that two specific tumor suppressor genes work in concert to inhibit the ...

Cancer created Apr 11, 2013 | popularity 5 / 5 (1) | comments 0

Rigosertib Phase 1 results lead to disease-focused Phase 2 development

Results of a phase 1 clinical trial reported at the American Association for Cancer Research (AACR) annual conference show that orally administered Rigosertib is well tolerated in patients with advanced solid tumors. This ...

Cancer created Apr 09, 2013 | popularity not rated yet | comments 0

Six2 homeoprotein allows breast cancer cells to detach and metastasize

In results presented at the AACR Annual Meeting 2013, researchers from the University of Colorado Cancer Center show that the Six2 homeoprotein, while not involved in primary tumor growth, allows cells to detach from substrate ...

Cancer created Apr 09, 2013 | popularity not rated yet | comments 0

Little molecule makes big difference in bladder cancer metastasis

In order to kill, bladder cancer must metastasize, most commonly to the lung – what are the differences between bladder cancers that do and do not make this deadly transition? Research presented by the Director of the University ...

Cancer created Apr 09, 2013 | popularity not rated yet | comments 0

Third-generation device significantly improves capture of circulating tumor cells

A new system for isolating rare circulating tumor cells (CTCs) – living solid tumor cells found at low levels in the bloodstream – shows significant improvement over previously developed devices and does ...

Cancer created Apr 03, 2013 | popularity not rated yet | comments 0 | with audio podcast

Landmark study describes prostate cancer metastasis switch

Prostate cancer doesn't kill in the prostate – it's only once the disease travels to bone, lung, liver, etc. that it turns fatal. Previous studies have shown that loss of the protein E-Cadherin is essential for this metastasis. ...

Cancer created Apr 02, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast

In managing inflammation, controlling white blood cell flow may be key

(Medical Xpress)—New research by Yale University scientists sets the stage for improved management of acute tissue inflammation related to wounds and chronic inflammatory diseases by advancing current understanding ...

Inflammatory disorders created Mar 28, 2013 | popularity 4.7 / 5 (3) | comments 0 | with audio podcast

Benefit of PET or PET/CT in bone and soft tissue tumors is not proven

For patients with bone and soft tissue tumours, the study data currently available allow no robust conclusions as to the advantages and disadvantages of using positron emission tomography (PET), alone or in combination with ...

Cancer created Mar 07, 2013 | popularity not rated yet | comments 0

Researcher examines mechanism underlying abdominal pain in pancreatic cancer

Erxi Wu, assistant professor of pharmaceutical sciences, co-wrote the article, "Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells," which was published by Molecular Cancer Re ...

Cancer created Mar 01, 2013 | popularity not rated yet | comments 0

Metastasis

Metastasis (Greek: displacement, μετά=next + στάσις=placement, plural: metastases), or Metastatic disease, sometimes abbreviated mets, is the spread of a disease from one organ or part to another non-adjacent organ or part. Only malignant tumor cells and infections have the established capacity to metastasize; however, this is recently reconsidered by new research.

Cancer cells can break away, leak, or spill from a primary tumor, enter lymphatic and blood vessels, circulate through the bloodstream, and settle down to grow within normal tissues elsewhere in the body. Metastasis is one of three hallmarks of malignancy (contrast benign tumors). Most tumors and other neoplasms can metastasize, although in varying degrees (e.g., glioma and basal cell carcinoma rarely metastasize).

When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are like those in the original tumor. This means, for example, that, if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. The tumor in the lung is then called metastatic breast cancer, not lung cancer.

For more information about Metastasis, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.

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