News tagged with molecule inhibitors
Researchers use new molecular inhibitors to successfully hit difficult cancer target
Early laboratory tests are the first to successfully use an experimental molecular therapy to block a hard-to-target part of a protein complex linked to several types of invasive cancer.
Cancer
Feb 05, 2013 |
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Discovery promises to improve drugs used to fight cancer, other diseases
(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...
Medical research
Jan 11, 2013 |
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New small molecule inhibitor could be a safe and first-line treatment for metastatic breast cancer
Previous research has shown that a family of genes, proteins and enzymes called the uPA system (for urokinase plasminogen activator) plays an active role in different facets of cancer's biology, including tumor cell invasion, ...
Cancer
Dec 08, 2012 |
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Making it easier to make stem cells
The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To ...
Medical research
Sep 25, 2012 |
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New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Individuals with mutations in BRCA1 and BRCA2 genes have a significantly higher risk of developing breast and ovarian cancers. Families at risk have been seeking genetic testing and counseling based on their mutation carrier ...
Cancer
Aug 06, 2012 |
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Catching the cap-snatcher: Structural analysis opens the way to new anti-influenza drugs
Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus' RNA polymerase, an enzyme that is crucial for influenza virus ...
Diseases, Conditions, Syndromes
Aug 02, 2012 |
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Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
Researchers at The Wistar Institute announce the discovery of small molecules that kill cancer cells caused by infection with human papillomavirus (HPV). Their results, in both cell and mouse models, demonstrate that the ...
Medical research
Apr 26, 2012 |
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Mutant Kras drives pancreatic cancer maintenance via metabolic pathways
A genetic mutation that drives the initiation of pancreatic cancer also manipulates metabolic pathways to support tumor growth and progression, scientists report in the journal Cell.
Cancer
Apr 26, 2012 |
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Unraveling why children with Down syndrome have increased leukemia risk
Children with Down syndrome (DS) have an increased risk of developing leukemia, in particular acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic leukemia (ALL). Through their studies in a mouse model of DS, a ...
Genetics
Feb 22, 2012 |
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Is it the alcohol or polyphenols in red wine that decreases cardiovascular disease?
Observational epidemiologic studies relating wine and alcohol to health all suffer from the fact that they, of necessity, compare people who prefer certain beverages, but not the beverages themselves. While there have been ...
Cardiology
Jan 17, 2012 |
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Small molecules can starve cancer cells
All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased ...
Cancer
Oct 09, 2011 |
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Enzymes possible targets for new anti-malaria drugs
Researchers at the Perelman School of Medicine at the University of Pennsylvania, Monash University, and Virginia Tech have used a set of novel inhibitors to analyze how the malaria parasite, Plasmodium falciparum, uses enzymes ...
Medical research
Sep 21, 2011 |
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P7 protein resistance mutations identified; represent drug targets for hepatitis C virus
British researchers have identified specific resistance mutations for two classes of p7 inhibitor, which may explain their lack of effectiveness in clinical trials combined with current standard of care. Study results support ...
Diseases, Conditions, Syndromes
Jun 28, 2011 |
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Move over Prozac: New drug offers hope for depression
The brain chemistry that underlies depression is incompletely understood, but research suggests that aberrant signaling by a chemical called Brain-Derived Neurotrophic Factor through its receptor TrkB, may contribute to anxiety ...
Medications
Apr 18, 2011 |
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New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
A study appearing in the journal Investigational New Drugs and conducted by researchers at Nationwide Children's Hospital, discovered that two new small molecule inhibitors are showing promise in blocking STAT3, a protei ...
Cancer
Apr 11, 2011 |
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