News tagged with mouse genome
Scientists find potential therapeutic target for Cushing's disease
Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this ...
Diseases, Conditions, Syndromes
May 07, 2013 |
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'Dark genome' is involved in Rett Syndrome
Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding ...
Genetics
May 02, 2013 |
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Transgenic mice ready to fight obesity—and more
Scientists at the Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw investigate mice with a very precisely modified genome. Because it is possible to turn off the Dicer ...
Genetics
Apr 25, 2013 |
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Completion of the zebrafish reference genome yields strong comparisons with the human genome
Researchers demonstrate today that 70 per cent of protein-coding human genes are related to genes found in the zebrafish and that 84 per cent of genes known to be associated with human disease have a zebrafish counterpart. ...
Genetics
Apr 17, 2013 |
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Comparing mouse and human immune systems: Few differences charted in map to translate mouse findings to humans
(Medical Xpress)—It is a familiar note struck when authors conclude their reports on experiments conducted in mouse models: They suggest caution when translating their findings from mouse to human. A variation ...
Medical research
Apr 02, 2013 |
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Mouse models fail to reproduce inflammatory genomic response to serious injuries
Existing mouse models do not appear to accurately reproduce the human genomic response to serious traumatic injury, including major burns, according to an article appearing in PNAS Early Edition.
Inflammatory disorders
Feb 11, 2013 |
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Combining plasma screening methods better identifies diagnostic and therapeutic targets
For the first time, scientists have combined genomic and proteomic analysis of blood plasma to enhance identification of genetically regulated protein traits. This could be applied to any large association study of civilization ...
Genetics
Feb 08, 2013 |
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Biomarker progress offers hope for early autism spectrum disorder detection
Autism spectrum disorders (ASD) are neurodevelopmental disorders typically characterized by difficulties in social interactions and delayed or abnormal language development. Although ASD reportedly affects 1 in 88 people ...
Autism spectrum disorders
Nov 30, 2012 |
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Studies in mice confirm that mutations in the gene, UBE3B, cause a rare genetic disorder in children
Researchers have defined the gene responsible for a rare developmental disorder in children. The team showed that rare variation in a gene involved in brain development causes the disorder. This is the first time that this ...
Genetics
Nov 29, 2012 |
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Researchers increase understanding of genetic risk factor for type 1 diabetes
As part of their ongoing research on the role of genes in the development of type 1 diabetes, Joslin Diabetes Center scientists, in collaboration with scientists at the University of Würzburg, have demonstrated ...
Diabetes
Nov 28, 2012 |
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Scientists discover gene switch important in cancer
Scientists at Karolinska Institutet in Sweden and the University of Helsinki in Finland have shown that the "switches" that regulate the expression of genes play a major role in the development of cancer. In a study, published ...
Cancer
Nov 01, 2012 |
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Inheritance of mitochondrial disease determined when mother is still an embryo
(Medical Xpress)—The risk of a child to inherit mitochondrial diseases - i. e. malfunction in what is usually referred to as the power plants of the cell - is largely decided when the future mother herself is still an embryo. ...
Genetics
Oct 08, 2012 |
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Protein inhibitor points to potential medical treatments for skull and skin birth defects
Researchers at Mount Sinai School of Medicine in New York have found new clues in the pathogenesis of skull and skin birth defects associated with a rare genetic disorder, Beare-Stevenson cutis gyrata syndrome (BSS). Using ...
Pediatrics
May 15, 2012 |
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Researchers identify promising new drug target for kidney disease
Researchers from Mount Sinai School of Medicine have identified a regulator protein that plays a crucial role in kidney fibrosis, a condition that leads to kidney failure. Finding this regulator provides a new therapeutic ...
Diseases, Conditions, Syndromes
Mar 11, 2012 |
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Drugs targeting chromosomal instability may fight a particular breast cancer subtype
Another layer in breast cancer genetics has been peeled back. A team of researchers at Jefferson's Kimmel Cancer Center (KCC) led by Richard G. Pestell, M.D., PhD., FACP, Director of the KCC and Chair of the Department of ...
Cancer
Feb 06, 2012 |
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