In 2003, the first year of her fellowship in pediatric oncology, two of Giselle Saulnier Sholler's first three patients had died from neuroblastoma, closely matching the 30% survival rate expected at the time for high-risk ...
Dec 15, 2023
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The WTX gene is mutated in approximately 30 percent of Wilms tumors, a pediatric kidney cancer. Like many genes, WTX is part of a family. In this case, WTX has two related siblings, FAM123A and FAM123C. While cancer researchers ...
Aug 30, 2012
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Chicago...Using state-of-the-art gene editing technology, scientists from Ann & Robert H. Lurie Children's Hospital of Chicago have discovered a promising target to treat atypical teratoid/rhabdoid tumor (AT/RT) - a highly ...
Apr 11, 2017
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(HealthDay)—Males may be the more vulnerable sex when it comes dying young—not just from accidents, but from a range of causes, a new study finds.
Sep 2, 2013
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Cancer drugs approved by the U.S. Food and Drug Administration (FDA) took a median of 6.5 years to go from the first clinical trial in adults to the first trial in children, according to a study at the Dana-Farber/Boston ...
May 21, 2019
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Researchers have confirmed that blocking an immune checkpoint molecule reduces tumor size and prolongs survival in animal models of the most aggressive childhood cancer. This study, carried out by researchers from Cima and ...
Oct 11, 2023
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Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision ...
Jun 23, 2022
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Genomic sequencing of tumors from pediatric cancer patients experiencing a relapse enabled 107 patients to receive an appropriate matched therapy that is not the standard of care, according to data from the international ...
Mar 16, 2022
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In a paper published in NAR Cancer, researchers from the Center for Childhood Cancer Research at Nationwide Children's and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of ...
Jun 14, 2023
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Young people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with ...
Aug 8, 2022
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