Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system's inflammation response to infection. ...
Aug 5, 2020
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213
Reperfusion therapy, the gold standard for stroke treatment, helps restore blood flow after a stroke caused by a clot, preventing loss of brain tissue. However, only about 10% of stroke patients qualify, in part because of ...
Jun 2, 2020
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123
The mechanisms of muscle function are not completely understood on the molecular level. Magnus Andersson and his research team have revealed how a protein that regulate muscle relaxation undergoes structural change in the ...
Mar 23, 2020
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247
Fresh insights into damaging proteins that build up in the brains of people with Alzheimer's disease could aid the quest for treatments.
Dec 10, 2019
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334
A high-salt diet may negatively affect cognitive function by causing a deficiency of the compound nitric oxide, which is vital for maintaining vascular health in the brain, according to a new study in mice from Weill Cornell ...
Oct 23, 2019
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1580
Long-term dialysis treatment is tough on the body in many ways, but one of the most serious complications is dialysis-related amyloidosis, a disease characterized by abnormal buildup of protein aggregates—called amyloid ...
Jul 8, 2019
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62
In a search for clues to what may delay or prevent Alzheimer's disease, Johns Hopkins Medicine scientists report that smarter, more educated people aren't protected from the disease, but do get a cognitive "head start" that ...
Jun 11, 2019
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306
A pair of collaborative studies led by Fen-Biao Gao, Ph.D., have identified two potential drug targets for the diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The studies, which appear in Nature ...
May 15, 2019
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140
Heart attack survivors may think the worst is behind them. But many later develop heart failure, a progressive disease marked by shortness of breath and swelling in the legs. Symptoms can prevent patients from working, exercising—even ...
Jan 28, 2019
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119
Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for ...
Dec 3, 2018
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44
