In an international Phase III randomized study, everolimus, when combined with the hormonal therapy exemestane, has been shown to dramatically improve progression-free survival, according to research from The University of ...
Dec 8, 2011
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Scientists at St. Jude Children's Research Hospital have visualized previously unknown structures of the ABL kinase, offering insight for designing the next generation of targeted therapies for adult and childhood cancers. ...
Oct 2, 2020
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Drugs that target BRAF and MEK in cancer have shown promise in treating a subset of melanoma that carries a mutation in the BRAF gene, but drug resistance usually emerges, reversing the benefit of these drugs and limiting ...
Dec 18, 2018
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A study of the DNA of more than 55,000 people worldwide has shed light on how we maintain healthy blood sugar levels after we have eaten, with implications for our understanding of how the process goes wrong in type 2 diabetes.
Jun 8, 2023
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German researchers unravel a critical regulatory mechanism controlling blood vessel growth that might help solve drug resistance problems in the future.
Mar 29, 2012
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Could fluctuations in body weight resulting from drastically cutting and increasing calories lead to physiological changes that raise the risk of heart disease or diabetes later in life?
Apr 1, 2022
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Sleeping sickness, or African trypanosomiasis, is caused by trypanosome parasites transmitted by tsetse flies and threatens millions of people in sub-Saharan Africa. The disease is considered fatal if untreated, but as it ...
Jun 25, 2015
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Targeted treatments have revolutionized care for lung cancer patients whose tumors harbor ALK or ROS1 alterations. Basically, cancers may use these genetic changes to drive their growth, but also become dependent on the action ...
Apr 11, 2018
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Researchers from the University of Michigan Rogel Cancer Center, studying the molecular landscape of over 500 patients with an aggressive form of multiple myeloma, discovered a prevalence of activated key oncogenic pathways ...
Jul 26, 2022
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(HealthDay) -- Only about 1 percent of very low birth weight (VLBW) infants develop methicillin-resistant Staphylococcus aureus (MRSA) infections, and the morbidity and mortality are similar to that seen in infants with methicillin-susceptible ...
Mar 12, 2012
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