News tagged with tamoxifen

Related topics: women · breast cancer · cancer cells · breast cancer patients · estrogen

Cold winters freezing out breast cancer treatment

For women diagnosed with a form of breast cancer known as estrogen receptor positive (ER+) breast cancer, tamoxifen is an essential drug used in the treatment and prevention of recurring breast cancer. Currently, tamoxifen ...

Apr 18, 2013
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10 years of tamoxifen better than 5, study reports

(HealthDay) —Taking the breast cancer drug tamoxifen for a decade, instead of the standard five years, further reduces the long-term chances of recurrence and risk of dying from the disease, new British research suggests.

Dec 05, 2012
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Tamoxifen

Tamoxifen is an antagonist of the estrogen receptor in breast tissue and is therefore used in the treatment of breast cancer. As of 2004, it was the world's largest selling drug for that purpose.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Furthermore tamoxifen prevents estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

Tamoxifen was discovered by ICI Pharmaceuticals (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."

This text uses material from Wikipedia, licensed under CC BY-SA

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