News tagged with transcription factors

Related topics: genes , cells , gene expression , stem cells , dna sequences

Some immune cells defend only one organ

(Medical Xpress)—Scientists have uncovered a new way the immune system may fight cancers and viral infections. The finding could aid efforts to use immune cells to treat illness.

Apr 17, 2014
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How developing sperm stick to the right path

The process of producing high-quality, fertile sperm requires many steps. A study in The Journal of Cell Biology shows how the transcription factor p73 promotes this process by regulating the adhesions betwee ...

Mar 24, 2014
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Defect in Ikaros gene mimics human B cell leukemia

Meinrad Busslinger and his team from the Institute of Molecular Pathology (IMP) investigate the differentiation of stem cells to mature B cells. They now present for the first time molecular details on the ...

Feb 11, 2014
popularity not rated yet | comments 0 | with audio podcast

Switching brain development on and off

(Medical Xpress)—The possibility of nerve cell regeneration is a step closer after neuroscientists identified the genetic signals that play a crucial role in normal development - driving stem cells to produce ...

Jan 30, 2014
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Predicting cancer's next move

Research led by Broad senior associate member Levi Garraway and published this week in Nature offers a new approach to studying drug resistance in cancer. The approach helped them identify which biological pathwa ...

Nov 11, 2013
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Transcription factor

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.

A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.

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