News tagged with transcription factors

Related topics: genes , cells , gene expression , stem cells , dna sequences

Fruit flies reveal features of human intestinal cancer

Researchers in Spain have determined how a transcription factor known as Mirror regulates tumour-like growth in the intestines of fruit flies. The scientists believe a related system may be at work in humans ...

Oct 08, 2014
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ZEB1, Oscar for leading role in fat storage

A team from Ecole polytechnique fédérale de Lausanne in Switzerland, in collaboration with ETH Zurich, has managed to decode the process of adipogenesis by identifying the precise proteins that play the ...

Oct 01, 2014
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Why the immune system fails to kill HIV

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus – and researchers ...

Jul 18, 2014
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Transcription factor

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.

A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.

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