Medical research

Elimination of senescent cells improves lung function in mice

Most cells can divide only a limited number of times and eventually undergo permanent cell cycle arrest, a state known as cellular senescence. Cellular senescence is mediated by activation of specific cellular signaling pathways ...

Genetics

Watching the luminescent gene switch

Scientists have found a way to simultaneously monitor the switching on and off of circadian "clock" genes and their effects on mouse behaviour in real-time.

Neuroscience

The brain clock that keeps memories ticking

Just as members of an orchestra need a conductor to stay on tempo, neurons in the brain need well-timed waves of activity to organize memories across time. In the hippocampus—the brain's memory center—temporal ordering ...

Diabetes

Sticky molecules to tackle obesity and diabetes

Okayama University researchers report that the over-expression of an adhesion molecule found on the surface of fat cells appears to protect mice from developing obesity and diabetes. The findings, published in the journal ...

Genetics

GM mice reveal the secret to a painless life

People born with a rare genetic mutation are unable to feel pain, but previous attempts to recreate this effect with drugs have had surprisingly little success. Using mice modified to carry the same mutation, UCL researchers ...

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