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Alzheimer's disease & dementia news

Medications

New drug screening method answers why Alzheimer's drugs fail, suggests new targets

By analyzing disease mechanisms in human neurons, researchers led by the University of California San Diego developed a new method to screen drugs for treating Alzheimer's disease. Their work sheds light on why Alzheimer's ...

Alzheimer's disease & dementia

Study now links non-mutated Apolipoprotein E to dementia in the aging brain

Researchers exploring dementia-related proteins in the brain identified Apolipoprotein E (ApoE) as a key misfolded protein. About 25% of individuals, and 50% of individuals with Alzheimer disease, have a genetic mutation, ...

Alzheimer's disease & dementia

People with dementia and the right to independent life

Experiences of people with dementia and their family members show researchers how a progressive illness affects the realization of the fundamental rights, and how the status of people with dementia can be improved.

Neuroscience

A cure for Alzheimer's is taking longer than expected; here's why

In her latest research paper, published in the Journal of Molecular Neuroscience, Anne Robinson, Head of Carnegie Mellon's Department of Chemical Engineering, explains why understanding the progression of neurodegeneration ...

Neuroscience

New findings for the function of tau in neurodegenerative disease

Utilizing cutting-edge proteomics, researchers at the Buck Institute and elsewhere have mapped the "tau interactome" uncovering new findings about the role of tau in neurodegenerative disease. Publishing in Cell, scientists ...

Diseases, Conditions, Syndromes

Can neonatal herpes lead to Alzheimer's disease?

"We've learned a lot during the course of the COVID-19 pandemic … how a virus can affect our behavior," Dartmouth University MD and Ph.D. candidate Abigail Dutton says in a short video that recently won second place in ...

Alzheimer's disease & dementia

Dementia: how to prevent cognitive decline

Physical activity, nutrition and cognitively stimulating activities are all known to be good ways to prevent Alzheimer's disease and dementia. And older adults at risk can access a variety of lifestyle services to that end, ...

Neuroscience

Understanding memory loss in Alzheimer's disease

Members of the Synaptic Dysfunction and Disease group at the Institute of Biomedicine of Seville (IBiS), led by researchers Francisco Gómez Scholl and Amalia Martínez Mir, recently published the results of their research ...

Alzheimer's disease & dementia

Senate committee backs califf nomination to head FDA

(HealthDay)—The nomination of former U.S. Food and Drug Administration head Robert Califf, M.D., to again lead the agency now heads to the full Senate for a vote, after a Senate committee on Thursday voted 13-8 for approval.

Medical research

Animal testing illuminates Alzheimer's

In Norway, more than 100,000 people live with Alzheimer's disease. Alzheimer's damages the central nervous system and alters memory, orientation and behavior. The disease becomes devastating once it has progressed and usually ...

Alzheimer's disease & dementia

Medicare limits coverage of $28,000-a-year Alzheimer's drug

Medicare said Tuesday it will limit coverage of a $28,000-a-year Alzheimer's drug whose benefits have been widely questioned, a major development in the nation's tug-of-war over the fair value of new medicines that offer ...

Psychology & Psychiatry

Cognitive decline not always a sign of Alzheimer's disease

At the first sign of cognitive trouble, people often worry Alzheimer's disease is forthcoming. But poor cognition can be part of the spectrum of normality in older age, according to new research published in JNeurosci.

Alzheimer's disease & dementia

Medicare told to reassess premium hike for Alzheimer's drug

U.S. health secretary Xavier Becerra on Monday ordered Medicare to reassess a big premium increase facing millions of enrollees this year, attributed in large part to a pricey new Alzheimer's drug with questionable benefits.

Alzheimer's disease & dementia

Exercise alters brain chemistry to protect aging synapses

When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found.

Alzheimer's disease & dementia

Aduhelm: Will Medicare cover the controversial Alzheimer's drug?

(HealthDay)—Following a months-long and unprecedented review, Medicare officials expect to announce within the next couple of weeks whether the program will cover the controversial Alzheimer's drug Aduhelm. The drug's ...

Alzheimer's disease & dementia

A new method for treating Alzheimer's disease

One in six Norwegians over 80 is affected by Alzheimer's disease. Numbers are even higher worldwide, and there is still no cure available.

Neuroscience

Research clears up how brain 'cleaners' fail in ALS

In preclinical studies, Mayo Clinic scientists and collaborators have identified the molecular mechanism used by the brain's "cleaners" as they remove a problematic protein in the brain. This work, published in Nature Neuroscience, ...

Neuroscience

Microglial methylation "landscape" in human brain

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across ...

Alzheimer's disease & dementia

Is energy the key to Alzheimer's disease?

A team of researchers at the University of Adelaide has found a link between the way that cells produce energy for brain function and the mutated genes found in Alzheimer's disease.

Neuroscience

Alternative strategy for stalling Alzheimer's neurodegeneration

Boosting levels of the neurotransmitter norepinephrine with atomoxetine, a repurposed ADHD medication, may be able to stall neurodegeneration in people with early signs of Alzheimer's disease, a study conducted at Emory Brain ...