Archive: 17/03/2016
Lamprey-derived antibody specifically recognizes human plasma cells
Antibody-secreting plasma cells arise from B cell precursors and are essential for adaptive immune responses against invading pathogens. Plasma cell dysfunction is associated with autoimmune and neoplastic disorders, including ...
Mar 17, 2016
A molecular subtype of bladder cancer resembles breast cancer
Bladder cancer is the fourth most common cancer among men in the United States. While low-grade tumors have a very favorable prognosis, muscle-invasive and metastatic tumors have poorer survival rates.
Mar 17, 2016
The genetic determinants of symptoms in a rare chromosomal deletion disorder
Individuals with 2p15p16.1 microdeletion syndrome present with intellectual disability, microcephaly, delayed growth, dysmorphic craniofacial features, and digital abnormalities. The precise genetic region responsible for ...
Mar 17, 2016
Cox2 inhibition improves preeclampsia symptoms in a mouse model
Preeclampsia is characterized by elevated blood pressure in the second half of pregnancy and impaired blood flow to the placenta, which increases the risk of premature birth and pregnancy complications.
Mar 17, 2016
Identification of a novel tyrosine kinase inhibitor for acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, ...
Mar 17, 2016
High viral load in HIV-infected individuals underlies innate immune cell dysfunction
Individuals infected with HIV exhibit both severe immune deficiency and aberrant inflammation, resulting in susceptibility to secondary infection as the disease progresses. HIV-associated deficiencies in adaptive immune responses ...
Mar 17, 2016
A pharmacological approach to improving pancreatic beta cell growth and function
β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in ...
Mar 17, 2016