A molecular subtype of bladder cancer resembles breast cancer

Bladder cancer is the fourth most common cancer among men in the United States. While low-grade tumors have a very favorable prognosis, muscle-invasive and metastatic tumors have poorer survival rates.

In this month's issue of JCI Insight, William Kim, Benjamin Vincent, and a research team from the University of North Carolina characterized a new subtype of muscle-invasive that shares molecular signatures with some forms of breast cancer. A subset of triple-negative breast cancers express low levels of the tight junction protein claudin. The UNC researchers now document that claudin-low tumors represent a specific subtype of bladder cancer as well.

Using data from the The Cancer Genome Atlas (TCGA) urothelial bladder carcinoma data set, they found that claudin-low tumors express high levels of immune-related genes, but also show a strong signature of immunosuppression. These finding suggest that claudin-low bladder cancers may be particularly responsive to immunotherapy-based treatments that derepress the immune system.

Future studies will be needed to clinically test immune checkpoint inhibitors in this population.


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Citation: A molecular subtype of bladder cancer resembles breast cancer (2016, March 17) retrieved 17 June 2019 from https://medicalxpress.com/news/2016-03-molecular-subtype-bladder-cancer-resembles.html
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