Rational protein engineering can improve effectiveness of mRNA therapies mRNA drugs offer a promising new approach to deliver therapeutic replacement proteins, and novel strategies designed to engineer more stable and active proteins are further enhancing the potential of mRNA therapies. Specific ... Mar 30, 2018 0 5
Pediatric cancer drug shows 93 percent response rate A first-of-its-kind drug targeting a fused gene found in many types of cancer was effective in 93 percent of pediatric patients tested, researchers at UT Southwestern's Simmons Cancer Center announced. Mar 30, 2018 0 1588
Non-invasive test can detect urothelial cancer (HealthDay)—UroSEEK, which uses DNA recovered from cells shed into urine, can detect urothelial cancer, according to a study published online March 20 in eLife. Mar 30, 2018 0 3
Structural studies help explain how cancer cells resist chemotherapy In order to kill cancer cells, chemotherapy drugs must first make their way inside them. But cancer cells are shrewd, and some use molecular pumps to expel the drugs before they have a chance to work. New research from Rockefeller's ... Mar 30, 2018 0 168
Relapse in major depression linked to brain cortical changes (HealthDay)—For patients with major depressive disorder (MDD), relapse is associated with brain cortical changes over two years, according to a study published online March 28 in JAMA Psychiatry. Mar 30, 2018 0 23
U.K. man found to have gonorrhea resistant to conventional treatments Researchers at Public Health England have announced, as reported by the BBC, that a U.K. man has contracted a case of gonorrhea that is resistant to the two types of antibiotics that are normally used to treat such infections. ... Mar 30, 2018 report 2 329
Traumatic brain injury rare for children with isolated vomiting (HealthDay)—Children presenting with head injury with isolated vomiting rarely have clinically important traumatic brain injury (ci-TBI) or traumatic brain injury on computed tomography (TBI-CT), according to a study published ... Mar 30, 2018 0 3
Losing children to foster care endangers mothers' lives Mothers whose children are placed in foster care are at much higher risk of dying young, particularly due to avoidable causes like suicide. Mar 30, 2018 0 29
Preventing tumors from shedding their identifying proteins allows immune system to attack A team of researchers with the Dana-Farber Cancer Institute and Brigham and Women's Hospital in the U.S. has found that introducing an antibody into a cancerous mouse model prevented the escape of ligands from a tumor surface ... Mar 30, 2018 report 0 96
Duration of antibiotics often exceeds guidelines for sinusitis (HealthDay)—The durations of most courses of antibiotic therapy for adult outpatients with sinusitis exceed guideline recommendations, according to a research letter published online March 26 in JAMA Internal Medicine. Mar 30, 2018 0 3