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Oncology news

Study points to broader stem cell donor options for blood cancer patients

For decades, stem cell transplantation has operated under a simple rule: The closer the donor match, the better. Patients with leukemia, lymphoma, myelodysplastic syndromes and other blood cancers often faced an extensive ...

Exploring precision medicine for pancreatic cancer

Imagine if, before starting cancer care, doctors could rapidly identify the most effective chemotherapy, immunotherapy or combination to personalize treatment for a loved one's hard-to-treat pancreatic cancer and improve ...

A unified framework to explain one of cancer's major drivers

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, Ph.D., associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham ...

How 'undead' cells trigger cancer-promoting inflammation

Stopping tumor growth is only half the battle. Rather than killing tumor cells, many cancer therapies can only push them into cellular senescence, a state in which cells stop dividing but do not die. These "undead" cells ...

How highly aggressive colon cancer evades the immune system

Researchers from the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have identified a previously unknown mechanism by which a particularly aggressive form of colon cancer evades the immune system.

Math and medicine join forces to solve a cancer mystery

Immunotherapy has transformed outcomes for many cancer patients. Unlike conventional treatments, these therapies do not attack tumors directly. Instead, they enable the body's immune system to identify and kill cancer cells ...

Newly found 'immune organ' inside skull directs brain defense

Researchers at Washington University School of Medicine in St. Louis have discovered lymph node-like structures in the skull bone marrow of mice for the first time and demonstrated that they act as rapid first responders ...

Breast cancers can recruit bone cells to increase tumor growth

Researchers at WashU Medicine have shown that cells originating in bone and best known for their role in bone formation are recruited to primary breast tumors, where they become cancer-associated fibroblasts, a type of cell ...

Electric fields offer new hope against aggressive brain cancer

More than a decade ago, Dr. Matthew Hebb was treating patients with Parkinson's disease using deep brain stimulation by implanting tiny electrodes into the brain and delivering electrical signals to control tremors. He wondered ...

Finding a tumor's soft spot to power-up immunotherapy

Researchers at the USC Viterbi School of Engineering and Keck School of Medicine of USC have engineered a genetic tool that addresses one of the most persistent obstacles in cancer immunotherapy: the physical softness of ...