Children with a variant in the SERPINE1 gene—which is found in 60% of the population—may be less responsive to mepolizumab, a drug used to treat asthma flares, according to a study published in the Journal of Allergy and ...
23 hours ago
0
7
A recent multicenter clinical trial has uncovered inflammatory pathways that contribute to asthma flare-ups in children that occur despite treatment, according to findings published in JAMA Pediatrics.
Aug 1, 2025
0
37
Biological drugs have improved the lives of many people with severe asthma. However, a new study from Karolinska Institutet in Sweden shows that some immune cells with high inflammatory potential are not completely eradicated ...
Jun 26, 2025
0
30
The U.S. Food and Drug Administration has approved GSK's Nucala (mepolizumab) as an add-on maintenance treatment for adult patients with inadequately controlled chronic obstructive pulmonary disease (COPD).
May 26, 2025
0
22
For patients with chronic obstructive pulmonary disease (COPD) with a history of exacerbations and a blood eosinophil count of at least 300 cells/µL, mepolizumab leads to a lower annualized rate of moderate or severe exacerbations, ...
May 12, 2025
0
16
An international collaboration of researchers, sponsored by GSK and working on behalf of the ANCHOR-1 and ANCHOR-2 trial investigators, conducted two Phase III clinical trials to evaluate depemokimab, an ultra-long-acting ...
An international team has identified a new therapeutic for patients with a rare autoimmune disease called eosinophilic granulomatosis with polyangiitis (EGPA). A biologic drug called benralizumab has been shown to be non-inferior ...
Feb 23, 2024
0
60
Asthma exacerbations are reduced for children and adolescents with exacerbation-prone eosinophilic asthma who are living in socioeconomically disadvantaged urban neighborhoods and receive mepolizumab therapy, according to ...
Aug 15, 2022
0
83
A National Institutes of Health clinical trial has found that a monoclonal antibody, mepolizumab, decreased asthma attacks by 27% in Black and Hispanic children and adolescents who have a form of severe asthma, are prone ...
Aug 10, 2022
0
69
