During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4). This protein can guide neuronal migration through ...
Apr 29, 2026
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The cerebral cortex, the brain's outermost region responsible for higher cognitive functions, depends on a highly ordered, layered structure. Its proper development requires newly generated neurons to migrate to precise locations ...
Feb 25, 2026
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Nearly 30 years ago, researchers began studying the gene Astn1, which encodes the cell adhesion protein astrotactin 1 in mice, and its role in brain development. During this time, they learned a great deal about the function ...
Feb 10, 2026
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Researchers in Taiwan and Belgium developed a lab-based diagnostic workflow that could help doctors predict the severity of a rare childhood brain disorder called FOXG1 syndrome (a rare neurodevelopmental disorder, like Rett ...
Jun 18, 2025
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In the developing brain, neurons must navigate through complex and often crowded tissue to reach their final destinations—this process is crucial for proper brain formation and function. Similar to how we might choose different ...
Apr 11, 2025
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What are the molecular and cellular mechanisms by which some babies develop epileptic encephalopathies and autism spectrum disorder? That's what researchers in Canada and France set out to uncover—and they think they've found ...
Oct 2, 2024
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The human brain continues to be built after we are born for far longer than previously recognized, suggests research by Shawn Sorrells, assistant professor of neuroscience in the Kenneth P. Dietrich School of Arts and Sciences. ...
Dec 20, 2023
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Researchers at the Instituto Gulbenkian de Ciência (IGC, Oeiras) and Max Planck Institute of Cell Biology and Genetics (MPI-CBG, Dresden) identified a new mechanism that exposes some of the multitasking abilities embryos ...
Aug 9, 2023
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The correct development of the brain cortex is an essential process for the acquisition of correct cognitive skills. Reelin, a key extracellular protein in neuronal migration and synaptic plasticity, is determinant in this ...
Sep 14, 2022
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Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain tissue models of Rett syndrome, ...
Jul 29, 2022
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