In a major step toward a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to block C. diff's most dangerous ...
Dec 9, 2025
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An international collaborative study has identified the E2F2 protein as a potential new therapeutic target to prevent metabolic fatty liver disease from progressing toward more serious conditions, such as cirrhosis or liver ...
Oct 22, 2025
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Aerobic exercise and a high capacity for exercise may protect against metabolic dysfunction-associated steatotic liver disease (MASLD), also known as fatty liver disease, by increasing the conversion of cholesterol into bile ...
Jul 16, 2025
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Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem cell-derived hepatic organoids, report researchers from Japan. These three-dimensional liver organoids ...
Jul 7, 2025
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The gut microbiome and the metabolites it produces offer promising insight into disease severity in critically ill patients. In a collaborative effort, researchers from the U.S. and the Netherlands developed the metabolic ...
A new study provides a comprehensive overview of the current state of metabolomics research in arterial stiffness on a less explored aspect: early vascular aging, particularly in adolescents. The study offers hope for innovative ...
Jun 5, 2025
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A new study reveals how a critical imbalance in bile acids—the substances made by the liver that help digest fats—can trigger liver diseases, including hepatocellular carcinoma (HCC), the most common form of liver cancer. ...
Apr 28, 2025
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When mothers eat a diet high in fat and sugars, their unborn babies can develop liver stress that continues into early life. A new study published in the journal Liver International sheds light on changes to the fetus's bile ...
Mar 13, 2025
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A recent study in an animal model provides direct evidence for the role of the vagus nerve in gut microbiome-brain communication, addressing a critical gap in the field.
Feb 11, 2025
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An antibiotic used to treat infective diarrhea could be an effective drug for a type of inflammatory bowel disease, a new study has found.
Feb 10, 2025
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