What is metastatic breast cancer, the type Olivia Newton-John had?
The death of Australian superstar Olivia Newton-John has drawn attention to an often misunderstood stage of breast cancer—metastatic breast cancer.
Aug 11, 2022
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The death of Australian superstar Olivia Newton-John has drawn attention to an often misunderstood stage of breast cancer—metastatic breast cancer.
Aug 11, 2022
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Breast cancer cells do not undergo a commonly accepted transformation in order to spread to distant organs such as the lungs, Weill Cornell Medicine investigators have found in a new study. This discovery may settle a longstanding ...
Nov 12, 2015
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Certain types of breast tumors can send signals that freeze the growth of their own secondary cancers, according to a major new study co-led by Australia's Garvan Institute of Medical Research.
Aug 27, 2018
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Scientists from The Scripps Research Institute (TSRI) have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for ...
Jan 11, 2018
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Exposure to dim light at night, which is common in today's lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study. Results of the study will be ...
Mar 23, 2019
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A novel approach to immunotherapy developed by researchers at the National Cancer Institute (NCI) has led to the complete regression of breast cancer in a patient who was unresponsive to all other treatments. This patient ...
Jun 4, 2018
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High cholesterol levels have been associated with breast cancer spreading to other sites in the body, but doctors and researchers don't know the cause for the link. A new study by University of Illinois researchers found ...
Oct 12, 2017
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Metastasis - or the spread of cancer from one part of the body to other parts - accounts for more than 90 percent of cancer-related deaths. Although the cells that seed metastasis and the sites that they tend to travel to ...
Dec 16, 2015
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Some cancers love bone. They thrive in its nutrient-rich environment while gnawing away at the very substrate that sustains them, all the while releasing inflammatory substances that cause pain—pain so severe that opioids ...
Sep 4, 2017
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(HealthDay)—Many women treated for early breast cancer overestimate the odds of it spreading to another organ, and those fears can diminish their quality of life, new research suggests.
Mar 4, 2016
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Metastatic breast cancer is a stage of breast cancer where the disease has spread to distant metastases. It is a complication of primary breast cancer, usually occurring several years after resection of the primary breast cancer. Metastatic breast cancer cells frequently differ from the preceding primary breast cancer in properties such as receptor status, have often developed resistance to several lines of previous treatment and acquired special properties that permit them metastasize to distant sites, making them especially dangerous. The prognosis is often poor, distant metastases are the cause of about 90% of deaths due to breast cancer.
Breast cancer primarily metastasizes to the bone, lungs, regional lymph nodes, liver and brain, with the most common site being the bone. Lymph node metastsasis into the sentinel node and few surrounding nodes is regarded as a treatable local event and not metastatic breast cancer, both when occurring at primary presentation or later.
Typical environmental barriers in a metastatic event include physical (a basement membrane), chemical (reactive oxygen species or ROS, hypoxia and low pH) and biological (immune surveillance, inhibitory cytokines and regulatory extra-cellular matrix (ECM) peptides) components. Organ-specific anatomic considerations also influence metastasis; these include blood-flow patterns from the primary tumor and the homing ability of cancer cells to certain tissues. The targeting by cancer cells of specific organs is probably regulated by chemo-attractant factors and adhesion molecules produced by the target organ, along with cell-surface receptors expressed by the tumor cells.
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