Genetics
How many babies die from genetic diseases because they're not tested? Too many, researchers say
Genetic diseases kill more infants than anyone realizes.
Feb 10, 2023
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Polycystic Kidney Disease
Medical research
Researchers identify a gene therapy target for polycystic kidney disease
Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern ...
Sep 16, 2022
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65
Medical research
Scientists use mini-kidney models to identify potential drugs for polycystic kidney disease
In a new study in Cell Stem Cell, scientists from the USC laboratory of Andy McMahon generated simple kidney-like structures called organoids and used them to identify potential drugs to treat adult-onset polycystic kidney ...
Jul 7, 2022
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Diseases, Conditions, Syndromes
Prevalence of chronic kidney disease among Auckland's Pacific population alarmingly high
Chronic kidney disease is "alarmingly" more prevalent among Auckland's Pacific population than previously thought, new University of Otago research reveals.
Mar 14, 2022
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Diseases, Conditions, Syndromes
New insights into kidney disease using tropical frog models
Using cutting-edge genetic engineering, UZH researchers have developed a model to study hereditary kidney disease with the help of tropical frogs. The method allows them to collect large amounts of data on anomalies, which ...
Nov 5, 2021
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2
Genetics
Study: Genetic kidney disorder reversible in preclinical models
Autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder, causes fluid-filled cysts to develop on the kidneys, which can impair their function. As part of the growth of cysts, the kidneys develop inflammation ...
Oct 13, 2021
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76
Diseases, Conditions, Syndromes
Chemical modification of RNA could play key role in polycystic kidney disease
A chemical modification of RNA that can be influenced by diet appears to play a key role in polycystic kidney disease, an inherited disorder that is the fourth leading cause of kidney failure in the U.S., UT Southwestern ...
Apr 14, 2021
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34
Diseases, Conditions, Syndromes
Research describes the diversity of genetic changes that cause inherited kidney disease in Ireland
A study has described genetic changes in patients with the most common form of hereditary kidney disease that affects an estimated 12.5 million people worldwide. The research, which focussed on Polycystic Kidney Disease (PKD) ...
Feb 8, 2021
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Diseases, Conditions, Syndromes
Scientists discover why a rare syndrome is giving people diseases linked to another group of genetic disorders
Zellweger syndrome is a rare disease which at its mildest form can cause developmental delays in childhood and vision and hearing loss in adulthood. At its most severe, it can mean weak muscle tone, feeding and respiratory ...
Sep 30, 2020
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1
Surgery
Pioneering dual surgery a safe option for patients with polycystic kidney disease
Patients with large polycystic kidneys in need of a kidney transplant can have their diseased kidneys safely removed laparoscopically at the same time as their transplant surgery. That is the finding of a Mayo Clinic study ...
Sep 29, 2020
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