By creating and manipulating mini-kidney organoids that contain a realistic micro-anatomy, UW Medicine researchers can now track the early stages of polycystic kidney disease. The organoids are grown from human stem cells.
Oct 2, 2017
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Hereditary and relatively common, polycystic kidney disease (PKD) has long been thought to be progressive and irreversible, condemning its sufferers to a long, slow and often painful decline as fluid filled cysts develop ...
Oct 18, 2019
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A cheap, safe and effective treatment to polycystic kidney disease may soon be available, thanks to a new national clinical out of Westmead, Australia, which is trialing water to treat the disease.
Jan 29, 2018
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Do you get up from your desk at work to refill your water bottle every time it runs out—even if you're not thirsty?
Jan 28, 2020
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(Medical Xpress)—A team of researchers from France, Germany and Belgium has found that giving a peptide found in green mamba venom to mice with a kidney disease led to reduced symptoms. In their paper published in Proceedings ...
A new technique for treating polycystic kidney disease has been identified by researchers at The University of Manchester and UCL.
Jun 3, 2015
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Using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD), according to two studies funded by the National Institutes of Health ...
Nov 15, 2014
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Scientists at Nanyang Technological University, Singapore (NTU Singapore) have successfully grown 'mini kidneys' in the lab and grafted them into live mice, revealing new insights into the metabolic defects and a potential ...
Apr 8, 2024
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A potential treatment for polycystic kidney disease—a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure—has shown promising results in animal testing.
Sep 12, 2019
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Type 1 diabetes patients with elevated albumin in their urine had three times the risk of life-threatening kidney and cardiac disease as those with normal levels, according to researchers at the University of Colorado Anschutz ...
Dec 8, 2016
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Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a cystic genetic disorder of the kidneys. There are two types of PKD: autosomal dominant polycystic kidney disease (ADPKD) and the less-common autosomal recessive polycystic kidney disease (ARPKD).
It occurs in humans and some other animals. PKD is characterized by the presence of multiple cysts (hence, "polycystic") typically in both kidneys; however 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood. The cysts are numerous and are fluid-filled, resulting in massive enlargement of the kidneys. The disease can also damage the liver, pancreas and, in some rare cases, the heart and brain. The two major forms of polycystic kidney disease are distinguished by their patterns of inheritance.
Polycystic kidney disease is one of the most common life-threatening genetic diseases, affecting an estimated 12.5 million people worldwide. In half of the people with polycystic kidney disease, there is no family history of the disease. In these cases, the gene coding for the disease occurs out of a spontaneous genetic mutation without either parent being a carrier of the gene.[citation needed]
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