Journal of Experimental Medicine

Cardiology

Scientists identify mutations in venous valve disease

A team of scientists has discovered that mutations in the genes FOXC2 and GJC2 are associated with defects in venous valves, flaps within veins that help maintain proper blood flow.

Medical research

Testicular macrophages are guardians of fertility

The origin, development, and characteristics of two types of testicular macrophage have been described by a CNRS team at the Centre d'Immunologie de Marseille-Luminy (CNRS / INSERM / Aix-Marseille University). To elucidate ...

Immunology

Scientists make critical insights into T-cell development

Mutations in the gene encoding the enzyme protein tyrosine phosphatase N2 (PTPN2) have been associated with the development of autoimmune disease including Type 1 diabetes, Crohn's Disease and rheumatoid arthritis.

Immunology

Scientists unearth cell 'checkpoint' that stops allergic diseases

Scientists from Trinity College Dublin have made a significant breakthrough in understanding the regulation of immune cells that play a pivotal role in allergic diseases such as asthma and eczema. They have identified a 'checkpoint' ...

Medical research

Researchers develop new method to generate human antibodies

An international team of scientists has developed a method to rapidly produce specific human antibodies in the laboratory. The technique, which will be described in a paper to be published July 24 in The Journal of Experimental ...

Medical research

Protein prevents excess fluid from entering lung tissue

A protein found in the cells lining blood vessels plays a central role in preventing fluid and inflammatory cells from leaking into lung tissue in a low-oxygen environment, Weill Cornell Medicine researchers discovered.

Diseases, Conditions, Syndromes

Scientists discover treatment target for pulmonary fibrosis

In new research published in the Journal of Experimental Medicine, Northwestern Medicine scientists have demonstrated that a unique population of immune cells plays a key role in the development of pulmonary fibrosis. They ...

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