Journal of Experimental Medicine

Oncology & Cancer

A better test for the tumor-targeting of CAR-T therapies

Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a ...

Immunology

The making of memory B cells and long-term immune responses

The current COVID-19 climate has made vaccines, antibodies and immune responses topics of everyday conversation. Now, it isn't just immunologists who want to know how our bodies respond to re-infections months, years, or ...

Medical research

A small T cell switch with a big impact

T cells play a key role in the human immune system. They are capable of distinguishing diseased or foreign tissue from the body's own, healthy tissue with great accuracy; they are capable of triggering the actions necessary ...

Medical research

A protein for the mass production of antibodies

Antibodies play a fundamental role in medicine, and antibody-mediated immune response is the ultimate target in the quest for a vaccine to defeat the current pandemic. These minute proteins, also called immunoglobulins, are ...

Genetics

DNA webs may drive lung pathology in severe COVID-19

Sticky webs of DNA released from immune cells known as neutrophils may cause much of the tissue damage associated with severe COVID-19 infections, according to two new studies published September 14 in the Journal of Experimental ...

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