Journal of General Physiology

Medical research

Geometry plays a role in GPCR transmembrane signaling

A recent study in The Journal of General Physiology characterizes the movement of rhodopsin, a GPCR and member of a large family of transmembrane receptors responsible for many cellular responses and involved in many human ...

Diseases, Conditions, Syndromes

How cholera-causing bacteria respond to pressure

Cholera remains common in non-industrialized parts of the world today. It persists in part because V. cholera, the bacteria that causes the disease, is able to survive in diverse environments ranging from the intestinal lumen, ...

Diseases, Conditions, Syndromes

Researchers explore PKC role in lung disease

New research examines the role of PKC in airway smooth muscle contraction and raises the possibility that this enzyme could be a therapeutic target for treating asthma, COPD, and other lung diseases.

Medical research

Fitting Kv potassium channels in the PIP2 puzzle

A recent study in the Journal of General Physiology brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2.

Medical research

Controlling our circadian rhythms

Most people have experienced the effects of circadian-rhythm disruption, after traveling across time zones or adjusting to a new schedule. To have any hope of modulating our biological "clocks," to combat jet lag or cope ...

Neuroscience

New insights into epilepsy drug Retigabine

A study published ahead of print in the The Journal of General Physiology has revealed new insights into Retigabine, a known pharmacological treatment for epilepsy.

Medical research

Protecting the skin from sun exposure

The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection ...

Medical research

A stable model for an unstable target

A study in The Journal of General Physiology provides new insights about singlet oxygen and sets the stage for better understanding of this highly reactive and challenging substance.

Medical research

Tweaking energy consumption to combat muscle wasting and obesity

Using a new technique to evaluate working muscles in mice, researchers have uncovered physiological mechanisms that could lead to new strategies for combating metabolism-related disorders like muscle wasting and obesity. ...

Medical research

Learning from scorpions to control impulses

Scorpions can teach us a lot about the benefits of prolonging nerve impulses, and we might now be better students thanks to a study published in The Journal of General Physiology. The results could pave the way for easier ...

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