Nature Immunology

Genetics

When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism

Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune system does not work properly, leading to increased susceptibility to various infections, autoimmunity, and cancers. ...

Diseases, Conditions, Syndromes

Deficient immune cells implicated in TB disease progression

Nearly a quarter of the world's population is estimated to be infected with Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, but less than 15 percent of infected individuals develop the disease.

Diseases, Conditions, Syndromes

A novel defense mechanism for SARS-CoV-2 discovered

Scientists from Hokkaido University have discovered a novel defensive response to SARS-CoV-2 that involves the viral pattern recognition receptor RIG-I. Upregulating expression of this protein could strengthen the immune ...

HIV & AIDS

Diabetes drug may be a new weapon against HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems ...

page 15 from 40