MeSH tree: G04.835.925
One of the main ways that the APOE4 gene variant, the biggest genetic risk factor for late-onset Alzheimer's disease, undermines brain circuit function is by disrupting the process of insulating neurons with a fatty sheath ...
Oct 15, 2026
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The liver is organized into distinct zones in which liver cells perform different functions. The blood vessels of the liver play an important role in this spatial organization: the endothelial cells lining the vessels provide ...
Oct 7, 2026
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A protein known as p53 is, of all tumor suppressors in human cancer, the most frequently altered by gene mutations. When mutations cause it to be absent or nonfunctional, its loss can allow populations of mutant cells to ...
Oct 1, 2026
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A signaling system known as the Wnt pathway plays a central role in how cells in the intestine grow, divide and renew themselves. Decades of research have shown that disruption of this pathway is a defining feature of many ...
Jun 12, 2026
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For most children diagnosed with medulloblastoma, the most common malignant pediatric brain tumor, survival rates are encouraging. But for a subset, remission is not the end of the story. Roughly 30% of patients will see ...
May 26, 2026
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A new preclinical study from Weill Cornell Medicine found that the protein caspase-5 (CASP5), long thought to be a foot soldier in the body's defense against bacterial infection, does not actually help clear invaders the ...
Apr 22, 2026
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Why does the same genetic mutation cause a severe brain malformation in some patients but not in others? Researchers from the MOSAIC team at the Paris Brain Institute have developed mosaic human cortical organoids carrying ...
Apr 16, 2026
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Researchers at Baylor College of Medicine have uncovered a previously unrecognized mechanism by which inherited calcium channel mutations disrupt early brain development and predispose children to epilepsy and related cognitive ...
Apr 3, 2026
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MDI Bio Lab scientists discovered how zebrafish solve a basic challenge in regenerative biology—insights in their newest publication in the journal Development could one day guide human repair.
Mar 17, 2026
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Liver cancer in children is rare, but when it occurs, the two main types are hepatoblastoma (HB) and hepatocellular carcinoma (HCC). In some cases, however, the tumors show features of both types. These tumors have been classified ...
Mar 16, 2026
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