MeSH tree: A11.284.430.106.279.345.574.813
Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the presence and absence ...
Jul 13, 2026
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3
Targeting cellular structures called nuclear speckles could be a completely new approach for treating proteinopathies—diseases driven by abnormal accumulation of misfolded proteins—such as Alzheimer's, Parkinson's and prion ...
Aug 11, 2025
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95
Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, Cold Spring ...
Jan 2, 2025
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38
