Congenital, Hereditary, and Neonatal Diseases and Abnormalities: News and Research on Polycystic Kidney, Autosomal Dominant

MeSH tree: C16.131.077.717.500

Single-dose base editing corrects PKD1 mutation and extends survival in ADPKD preclinical models

Mayo Clinic researchers have developed a promising gene-editing therapy that directly corrects a genetic mutation responsible for autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disorder.

Jan 29, 2026

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Major complications seen in 7% of patients with ADPKD undergoing nephrectomy

Major complications occur in 7.0% of patients undergoing nephrectomy with a diagnosis of autosomal dominant polycystic kidney disease (ADPKD), according to a study published online Dec. 17 in Urology Practice.

Dec 23, 2025

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