Clinical Trials, Phase I as Topic - Medical News and Research Articles

Egyptian group developing Ebola vaccine

An Egyptian pharmaceutical firm is developing a potential vaccine against the deadly Ebola strain raging in the Democratic Republic of Congo (DRC), it announced Thursday.

Aug 27, 2026

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First person vaccinated during trial of new Ebola jab

A volunteer was injected Friday with the first dose of a rapidly developed vaccine targeting the Bundibugyo strain of Ebola driving a deadly outbreak in the Democratic Republic of Congo, Oxford University said.

Jul 24, 2026

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New malaria drug candidate shows promise in Phase I trial

The early-stage trial of a potential novel nonartemisinin malaria drug found it rapidly killed malaria parasites and was generally well tolerated in infected volunteers, showing it is a promising candidate for uncomplicated ...

Jul 15, 2026

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First-in-human immunotherapy more than doubles progression-free survival in glioblastoma patients

Glioblastoma, the most aggressive malignant brain tumor in adults, remains one of the most challenging cancers to treat because of limited treatment options and a poor prognosis. Patient outcomes have remained largely unchanged ...

Jul 10, 2026

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AI-aided 'master key' vaccine may block entire virus families, not single strains

Known by acronyms that need no explanation, viruses like COVID, SARS and Ebola conjure images of medics in protective suits and spark fear in populations worldwide.

Jun 25, 2026

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First‑in‑human study tests gamitrinib designed to disrupt cancer cells' energy systems

Cancer cells need large amounts of energy to survive and multiply. To produce that energy, they rely on structures inside the cell called mitochondria, often described as the cell's "powerhouse." Unlike healthy cells, cancer ...

Jun 2, 2026

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Experimental KRAS G12D drug slows cancer growth, shrinks tumors in early test

A first-in-human clinical trial led by an international team of researchers and published in the New England Journal of Medicine found that setidegrasib, an investigational targeted therapy drug designed to eliminate a key ...

May 2, 2026

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Intralesional nivolumab may be effective against precancerous oral lesions, Phase I trial results indicate

Injecting nivolumab (Opdivo) directly into precancerous oral lesions led to a reduction in lesion size and allowed some patients to avoid surgery, according to research from a Phase I clinical trial presented at the American ...

Apr 21, 2026

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Distribution of Phase I lung cancer trials may be consolidating at top-performing US sites

Between 2020 and 2024, the number of unique sites in the United States where phase I clinical trials for non-small cell lung cancer (NSCLC) were conducted decreased by 44% and became increasingly concentrated at the top 20 ...

Apr 20, 2026

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KRAS(ON) inhibitor zoldonrasib showed effective, durable responses in patients with advanced G12D-mutated lung cancer

The investigational KRAS G12D inhibitor zoldonrasib showed evidence of clinical activity and a favorable safety profile in patients with previously treated non-small cell lung cancer (NSCLC) whose tumors harbored a KRAS G12D ...