MeSH tree: D08.811.399
A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological ...
Aug 8, 2024
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Northwestern Medicine scientists have discovered new insights into the production and regulation of a class of noncoding RNAs and how alterations in their signatures diversify and modulate the transcriptome of three major ...
Aug 5, 2024
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A new publication in Science Advances from researchers at Karolinska Institutet shows how to use a specific cancer trait to improve treatment of pancreatic tumors.
Nov 1, 2023
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Scientists studying how poxviruses evade natural defenses in human cells have identified a new approach to treatment that may be more durable than current treatments.
Aug 9, 2023
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A new research paper has been published in the journalOncotarget entitled, "Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells." Diphenyl ditelluride (DPDT) is an ...
Jun 26, 2023
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Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these cancer cells move through ...
Jun 15, 2023
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Neil Osheroff, John Coniglio Chair in Biochemistry and professor of biochemistry and medicine, is part of an international research collaboration resulting in what is on track to be the first new antibiotic treatment for ...
Jan 30, 2023
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The processes of DNA replication and transcription may introduce torsional (or twisting) strains in the DNA structure. These topological problems are relieved by an enzyme called topoisomerase II (TOP2) via a series of reactions.
Jan 18, 2023
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The structure of chromatin—the mixture of DNA and proteins that form chromosomes—can affect gene expression, and certain chromatin "readers" are important for monitoring this structure often in response to environmental cues.
Aug 22, 2022
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Computational modeling has been used to create dual-action compounds with exciting potential as new antibiotics. The proof of principle experiment raises the possibility of new antibiotics that can target harmful bacteria ...
Jul 28, 2022
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