MeSH tree: G05.219
In a new study published in the Journal of Hepatology, researchers from the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) show that only 15–20% of hepatocytes in newborn mice—dubbed clonogenic hepatocytes—are ...
Aug 28, 2025
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Triple-negative breast cancer (TNBC), the deadliest breast cancer subtype, disproportionately affects African American women—but until now, they have been underrepresented in genomic studies aimed at identifying the genetic ...
Aug 26, 2025
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Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and senescence-like responses ...
Jun 3, 2025
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By combining information from many large datasets, MIT researchers have identified several new potential targets for treating or preventing Alzheimer's disease.
May 20, 2025
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Fanconi anemia is an aggressive, life-threatening disorder. Most individuals living with this rare genetic condition, characterized by bone marrow failure and cancer predisposition, survive into adulthood only with bone marrow ...
May 8, 2025
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An FDA-designated orphan drug that can target a key vulnerability in lung cancer shows promise in improving the efficacy of radiation treatments in preclinical models, according to a study by UT Southwestern Medical Center ...
May 1, 2025
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For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy and was generally well-tolerated, ...
Apr 28, 2025
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A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes.
Apr 22, 2025
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A study led by Prof. Liu Feng from the Institute of Zoology of the Chinese Academy of Sciences has identified a crucial role for the tryptophan-aspartic acid (WD) repeat protein 5 (Wdr5) in maintaining the survival and genomic ...
Mar 25, 2025
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Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or inactivating genes. Precisely fixing disease-causing mutations is far more difficult. This is especially ...
Feb 12, 2025
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