Macromolecular Substances: News and Research on Protein Aggregates

MeSH tree: D05.875

Cracking the code of p53 fragility: Why the genome guardian is prone to failure

The protein p53 is often called the guardian of the genome for its central role in preventing cancer. Yet paradoxically, it is also one of the most frequently mutated and dysfunctional proteins in human tumors.

May 20, 2026

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Why only some patients get liver disease: New protein pathway may help forecast alpha1-antitrypsin outcomes

Alpha1-antitrypsin deficiency, an inherited disorder affecting 100,000 people in the U.S., causes a progressive and incurable lung disease. A subset of patients with the condition—about 10% to 15%—also develop liver disease ...

May 17, 2026

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