Natural substance can block a newly discovered cancer cell energy pathway
Looking to nature for answers to complex questions can reveal new and unprecedented results that can even affect cells on molecular levels.
Jun 10, 2025
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Metabolism: News and Research on Glycolysis
MeSH tree: G03.191.750
How tau protein weakens the brain's vascular defenses in Alzheimer's disease
A harmful form of the tau protein, which builds up in Alzheimer's disease and similar brain disorders, can directly damage blood vessels in the brain, according to a new study by researchers at the Lewis Katz School of Medicine ...
Apr 29, 2025
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Epstein-Barr virus aggravates ulcerative colitis via macrophage pyroptosis: Findings could yield new therapeutic target
A recent study has revealed how Epstein-Barr virus (EBV) intensifies ulcerative colitis (UC), a debilitating inflammatory bowel disease. Researchers discovered that EBV infection triggers macrophage pyroptosis—a form of inflammatory ...
Mar 24, 2025
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Metabolic activities are not global modulators of developmental tempos, study finds
A new study from EMBL Barcelona researchers shows that metabolic activities selectively modulate the segmentation clock, which varies depending on the species.
Jan 30, 2025
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An energy trap for tumor cells: Researchers find enzyme blockade halts liver cancer growth
Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis, a phenomenon known as the Warburg effect. ...
Jan 21, 2025
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Powering brain health: How autophagy protects neurons by controlling their glucose consumption
Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained elusive.
Jan 15, 2025
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HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ...
Dec 14, 2024
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Colon cancer risk linked to p53 gene in ulcerative colitis
Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in Science Advances, suggests ...
Oct 25, 2024
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Glucose metabolism drives embryonic development in mice, study reveals
Yale University researchers have discovered that glucose metabolism plays a critical role in guiding the early development of mouse embryos, revealing that specific metabolic pathways regulate essential cell signaling during ...
Study: DOCK8 mutation disrupts helper T cell differentiation via glycolytic pathway regulation
A study, published in the journal MedComm and led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the dedicator of cytokinesis 8 (DOCK8) gene in the differentiation of helper ...
Oct 9, 2024
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