MeSH tree: G03.493
Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis, a phenomenon known as the Warburg effect. ...
Jan 21, 2025
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28
Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the precise mechanisms by which autophagy maintains brain health have remained elusive.
Jan 15, 2025
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63
Mitochondria are vital to energy production in cells and so play a key role in fueling cancer growth. However, how mitochondrial DNA (mtDNA) contributes to cancer has been unclear.
Jan 2, 2025
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125
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ...
Dec 14, 2024
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37
Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in Science Advances, suggests ...
Oct 25, 2024
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56
Yale University researchers have discovered that glucose metabolism plays a critical role in guiding the early development of mouse embryos, revealing that specific metabolic pathways regulate essential cell signaling during ...
A study, published in the journal MedComm and led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the dedicator of cytokinesis 8 (DOCK8) gene in the differentiation of helper ...
Oct 9, 2024
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Researchers at Baylor College of Medicine and collaborating institutions have discovered a mechanism that drives the long-term decline in immune response that is observed after tuberculosis (TB) has been successfully treated. ...
Sep 30, 2024
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Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by researchers at Weill Cornell ...
Sep 26, 2024
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Results from a preclinical study in mice led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response—associated with parasitic infection and thought to play a negative role in cancer immunity—is ...
Sep 26, 2024
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