Developing treatment strategies for an understudied bladder disease
Despite its increasing prevalence, a painful condition called bladder pain syndrome, or interstitial cystitis, remains understudied with limited treatment options.
Mar 10, 2025
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Nervous System Diseases: News and Research on Chorea
MeSH tree: C10.228.662.262.249
Reducing DNA repair protein levels to target root cause of Huntington's disease
Researchers from the Huntington's Disease Center, UCL Queen Square Institute of Neurology, and UK DRI at UCL have taken major steps forward in advancing MSH3-targeting therapies for Huntington's disease (HD). Their study ...
Feb 19, 2025
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New study reveals how DNA repair genes play a major role in Huntington's disease
A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream ...
Feb 11, 2025
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Brain changes in Huntington's disease decades before diagnosis may guide future prevention trials
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately 20 years before a clinical motor diagnosis in people with Huntington's disease, finds a study led by ...
Jan 17, 2025
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Surprising way that genetic mutation causes Huntington's disease changes understanding of the disorder
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to ...
Jan 16, 2025
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Immunofluorescence study sheds light on brain's DNA damage and repair processes
Brain cells receive sensory inputs from the outside world and send signals throughout the body telling organs and muscles what to do. Although neurons comprise only 10% of brain cells, their functional and genomic integrity ...
Jan 13, 2025
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Antiviral protein causes genetic changes implicated in Huntington's disease progression
People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time. The cause is related to expansion of repeating DNA units, in which specific strings of genetic ...
Jan 9, 2025
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Discovery of molecular mechanisms offers new targets for Huntington's treatment
A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such ...
Jan 8, 2025
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Computer simulations detail 'protein clumps' linked to Huntington's disease
University of Bergen researcher Markus Miettinen is among the first scientists to provide a detailed description of protein clumps associated with Huntington's disease. The findings, which could pave the way for new diagnostic ...
Jan 7, 2025
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How chronic illness affects families—and how to cope when you know your loved one is going to die
Living with a chronic illness in the family is hard. It's even harder if you know that the person you love will get worse and won't recover from their condition. Sadly, it can happen to any family at any time. Anyone—a grandparent, ...
Jan 3, 2025
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