Proteins could relate to increased longevity in women

Scientists in Spain and Italy have identified a group of proteins in laboratory rats that could help explain two enduring medical mysteries — why women live longer than men and why calorie restriction stands as the only proven method of extending longevity. Their study, which could help scientists understand the biochemical underpinnings of aging, is scheduled for the July 3 issue of ACS' monthly Journal of Proteome Research.

In the study, Adamo Valle and colleagues point out that women, on average, live years longer than men. Previous studies also have shown that diets extremely low in calories consistently increase maximum life spans in a wide range of animals. Scientists have speculated that the explanation may involve hormones, stress, cardiovascular protection and other factors.

Using lab rats as stand-ins for humans, the researchers found that the livers of both female rats and calorie-restricted rats produced different levels of 27 proteins than male rats or those on a normal diet.

The findings suggest that a previously unrecognized set of cellular pathways may be involved in the longevity boost from being female and eating a sparse diet, the study says, suggesting that these insights could lead to new ways of boosting human longevity.

Citation: dx.doi.org/10.1021/pr800086t

Source: ACS


Explore further

Scientists find differences in naked mole rat's protein disposers

Citation: Proteins could relate to increased longevity in women (2008, June 30) retrieved 24 June 2019 from https://medicalxpress.com/news/2008-06-proteins-longevity-women.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more