DKK-3 and WIF-1: Proteins related to liver cancer development?

June 15, 2009

Liver cancer is one of the most fatal human malignancies and the third most frequent cause of tumor-related death, about half a million people globally each year. The current methods used to monitor such high-risk groups include ultrasound scans and a test for the presence of a single protein in the blood called alpha-fetoprotein. It is a good indicator of advanced liver cancer, but less able to detect early disease. So it is the most impotent thing is find the changes of biomarker combinations in the early period of diseases, control the key gene in the initial stage of disease and reverse the development of disease.

Wnt signal transduction pathway was significantly related to human neoplastic transformation. The Wnt-antagonist genes function as tumor suppressors and contribute to the pathogenesis of several human malignancies. Such as the promoter-hypermethylation and reduced expression of the DKK-3 gene was found in bladder cancer, lung cancer cell lines and tissues, the WIF-1 gene was found in lung cancer cell lines and tissues, malignant pleural mesothelioma cell lines and tissues, and nasopharyngeal cancer cell lines, also.

A research article to be published in the World Journal of Gastroenterology addresses this question. The study suggested the proteins transcripted by DKK-3 and WIF-1 can act as cancer-associated proteins relate with development, but it isn't the same mechanism with (HBV) infection reducing the liver cancer development. The author identified that the silence of DKK-3 and WIF-1 gene resulted from the hypermethylation of its promoter maybe one of carcinogenic factors related to age and apart from HBV infection and the expression of DKK-3 is negatively related to the stage of tumor and cell proliferation. All of this suggested DKK-3 and WIF-1 have great potential to be identified as cancer-associated proteins in the liver . It may be provide a reliable way to improve liver cancer early diagnosis and new therapies by blocking this pathway to treatment of liver cancer through further study.

Source: World Journal of Gastroenterology (news : web)

Related Stories

Recommended for you

No dye: Cancer patients' gray hair darkened on immune drugs

July 21, 2017
Cancer patients' gray hair unexpectedly turned youthfully dark while taking novel drugs, and it has doctors scratching their heads.

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

July 19, 2017
The most comprehensive analysis yet of medulloblastoma has identified genomic changes responsible for more than 75 percent of the brain tumors, including two new suspected cancer genes that were found exclusively in the least ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.