Clinical trials of spray-on skin to start in US

November 24, 2009 by Lin Edwards weblog

(PhysOrg.com) -- Clinical trials comparing a spray-on skin product with skin grafts will start in the US in December. The trials, which are partly funded by a US army grant of $1.4 million, will last about a year and will involve 106 patients with second degree burns. The product, ReCell, has been available for some time in Europe, Australia, Malaysia and elsewhere, and was approved for use in China earlier this year.

ReCell is one of two products developed in the burns unit of the Royal Perth Hospital in Western Australia by burns expert Dr Fiona Wood, who was named Australian of the year in 2005. ReCell was first successfully used in 2002 to treat burns victims of the Bali bombings terrorist attacks. ReCell is used to heal small burns, and to re-pigment old scars or blotchy conditions such as vitiligo. For larger burns, CellSpray is used instead. Both ReCell and CellSpray are products of the Clinical Cell Culture (C3) technology invented by Dr Wood.

The C3 kit is a little larger than a sunglasses case and has everything needed to create the spray. A small piece of skin, approximately the area of a postage stamp and around 0.015 cm deep is harvested from the patient's healthy skin. The sample contains basal cells and melanocytes, which are dissolved in a solution containing the enzyme trypsin.

The cells are processed and grown, and then the solution is sprayed on the area to be treated. The wound is dressed and the dressing is removed 3-5 days later, by which time the sprayed cells have multiplied and are forming new skin.

In vitiligo and old scar treatments the melanocytes () are most important. A sample of skin of the required color is taken, and the cells are processed and grown in the kit. The solution containing the cells is then sprayed on and the new skin that grows has the same color as the sample.

Dr Woods said that in the Royal Perth Hospital burns unit the products have dramatically reduced follow-up work in burns patients because the wounds heal faster and there is less scarring. Woods and scientist Marie Stoner together formed a company, the McComb Foundation, to further research ways of healing burns quickly and reducing scarring.

Efforts to market ReCell and CellSpray globally began in Europe, followed by Asia. After success in these markets the next goal is the US. The FDA is expected to approve ReCell if the US clinical trials are as successful as they have been elsewhere. The product should be available shortly after it is approved for release.

© 2009 PhysOrg.com

Related Stories

Recommended for you

Link between cells associated with aging and bone loss

August 21, 2017
Mayo Clinic researchers have reported a causal link between senescent cells - the cells associated with aging and age-related disease - and bone loss in mice. Targeting these cells led to an increase in bone mass and strength. ...

Make way for hemoglobin

August 18, 2017
Every cell in the body, whether skin or muscle or brain, starts out as a generic cell that acquires its unique characteristics after undergoing a process of specialization. Nowhere is this process more dramatic than it is ...

Bio-inspired materials give boost to regenerative medicine

August 18, 2017
What if one day, we could teach our bodies to self-heal like a lizard's tail, and make severe injury or disease no more threatening than a paper cut?

Are stem cells the link between bacteria and cancer?

August 17, 2017
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori, ...

Two-step process leads to cell immortalization and cancer

August 17, 2017
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated process than originally ...

New Pathology Atlas maps genes in cancer to accelerate progress in personalized medicine

August 17, 2017
A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

antialias
4 / 5 (1) Nov 24, 2009
This seems like a pretty significant tool (and not just some theoretical research). Could have very wide applications in post-OP.

Should also be very interesting to all kinds of people doing (or failing at) cosmetic surgery.

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.