Flaxseed oil and osteoporosis

November 23, 2009

Animal studies suggest that adding flaxseed oil to the diet could reduce the risk of osteoporosis in post-menopausal women and women with diabetes, according to a report to be published in the International Journal of Food Safety, Nutrition and Public Health.

Mer Harvi and colleagues at the National Research Center, in Cairo, Egypt, have studied the effect of diabetes on bone health and evaluated how flaxseed oil in the diet might delay the onset of . The researchers studied 70 female albino rats of which 30 had their ovaries removed (ovx) to simulate the post-menopausal state and experimental diabetes was present in one group of rodents.

The researchers then classified the rats as control, sham, diabetic, diabetic received flaxseed oil in the diet, ovx, ovx-diabetic and ovx-diabetic received flaxseed oil in the diet.

After two months, the team collected urine and blood samples from the rats and measured serum insulin-like growth factor 1 (IGF-1) and the bone-creating protein osteocalcin. They found that these two compounds were present at higher levels in the ovx and the diabetic ovx groups, but much lower in the non-ovx diabetic group. The concentrations of IGF-1 and osteocalcin could be raised to normal levels by adding flaxseed oil to the diet.

The team also found that the levels of deoxypyridinoline in the urine were raised in the diabetic group. Deoxypyridinoline is normally present in healthy bone and its presence in urine is a specific marker for bone resorption associated with osteoporosis. Levels of this marker compound fell when the rats were given flaxseed oil.

The team concludes that diabetes has a more pronounced effect on bone health than ovariectomy and so may suggest that diabetes in post-menopausal women may also be a greater risk factor for osteoporosis than the decline in associated with the menopause. However, their results suggest that flaxseed oil has a beneficial effect on and reduces markers associated with osteoporosis, suggesting that this dietary supplement could be beneficial to women with diabetes in reducing their risk of osteoporosis.

The team explains that the presence of so-called "n-3 fatty acids" in flaxseed oil may play a role in protecting the processes of matrix formation and bone mineralization, which are apparently compromised by and the menopause. "We recommend further investigations using animals and humans to confirm the effect of using dietary flaxseed oil to improve bone health and to prevent osteoporosis," Harvi and colleagues conclude.

More information: "Impact of feeding flaxseed oil on delaying the development of osteoporosis in ovariectomized diabetic rats" in Int. J. Food Safety, Nutrition and Public Health, 2009, 2, 189-201.

Source: Inderscience Publishers (news : web)

Related Stories

Recommended for you

Gulf spill oil dispersants associated with health symptoms in cleanup workers

September 19, 2017
Workers who were likely exposed to dispersants while cleaning up the 2010 Deepwater Horizon oil spill experienced a range of health symptoms including cough and wheeze, and skin and eye irritation, according to scientists ...

India has avoided 1 million child deaths since 2005, new study concludes

September 19, 2017
India has avoided about 1 million deaths of children under age five since 2005, driven by significant reductions in mortality from pneumonia, diarrhea, tetanus and measles, according to new research published today.

Today's US teens about three years behind '70s generation

September 19, 2017
Teenagers in America today are about three years behind their counterparts from the 1970s when it comes to taking up sex, drinking alcohol and working for pay, researchers said Tuesday.

Study suggests link between youth football and later-life emotional, behavioral impairment

September 19, 2017
A new study has found an association between participation in youth tackle football before age 12 and impaired mood and behavior later in life. The study appears in Nature's Translational Psychiatry.

Self-confidence affected by teammates, study finds

September 19, 2017
A person's confidence in their own ability varies significantly depending on who is in their team, according to new research from the University of Stirling.

Video game boosts sex health IQ and attitudes in minority teens

September 18, 2017
A videogame designed by Yale researchers to promote health and reduce risky behavior in teens improves sexual health knowledge and attitudes among minority youth, according to a new study. The findings validate the value ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.