Research looks at cooling off hot flashes

September 16, 2010
Woman trying to cool of a hot flash

If you've ever watched a woman go from perfectly calm, cool and collected one minute to uncomfortable, red-faced and fanning herself frantically the next, then you've likely witnessed a hot flash. Now imagine having to experience one or dozens of these episodes a day -- from mild to severe -- with limited options for long-term relief.

"Probably 80 percent of women use nothing” to treat their hot flashes, says University of Cincinnati (UC) professor Michael Thomas, MD, the principal investigator on a Phase 2 clinical trial of a new, nonhormonal treatment for hot flashes.

The study is sponsored by Ausio, a Cincinnati-based pharmaceutical company. UC is one of two sites in the U.S. where the soy-based product is being studied.

Although there is no definitive cause for a hot flash, its origin is linked to estrogen diminishment during perimenopause, menopause and post menopause. (HRT) was the standard treatment until 1991, when a study suggested that therapy increased the risk of , , and other serious conditions, says Thomas.

"These fears, whether rational or not, have driven the need to look for alternative treatments,” adds Thomas, who is also the director of UC’s Center for Reproductive Health which oversees clinical trials.

Not all women have hot flashes, but those who do can experience one or all of these symptoms:

• Pressure in the head as the hot flash begins.

• A feeling of mild warmth to intense heat spreading through the upper body and face.

• A flushed appearance with red, blotches on the face, neck and upper chest.

• Rapid heartbeat.

• Perspiration, mostly on the upper body.

• A chilled feeling as the hot flash subsides.

According to Rose Maxwell, PhD, the center’s director of clinical trials, this study is for post menopausal females who experience moderate to severe hot flashes but are not on any medication, either chemical or herbal. A moderate hot flash is one that produces perspiration. A severe hot flash produces perspiration and is incapacitating to the point of disrupting normal activities, such as sleep.

The study will compare the effectiveness and safety of three doses of the soy-based Ausio product versus a placebo (an inactive look-alike substance) for hot flashes.

Thomas is a past paid consultant to Ausio. He reports no current conflict.

Related Stories

Recommended for you

Exploring the potential of human echolocation

June 25, 2017
People who are visually impaired will often use a cane to feel out their surroundings. With training and practice, people can learn to use the pitch, loudness and timbre of echoes from the cane or other sounds to navigate ...

Team eradicates hepatitis C in 10 patients following lifesaving transplants from infected donors

April 30, 2017
Ten patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease. The findings point to new strategies for increasing ...

'bench to bedside to bench': Scientists call for closer basic-clinical collaborations

March 24, 2017
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX), National Human Genome Research ...

The ethics of tracking athletes' biometric data

January 18, 2017
(Medical Xpress)—Whether it is a FitBit or a heart rate monitor, biometric technologies have become household devices. Professional sports leagues use some of the most technologically advanced biodata tracking systems to ...

Financial ties between researchers and drug industry linked to positive trial results

January 18, 2017
Financial ties between researchers and companies that make the drugs they are studying are independently associated with positive trial results, suggesting bias in the evidence base, concludes a study published by The BMJ ...

Best of Last Year – The top Medical Xpress articles of 2016

December 23, 2016
(Medical Xpress)—It was a big year for research involving overall health issues, starting with a team led by researchers at the UNC School of Medicine and the National Institutes of Health who unearthed more evidence that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.