'Un-growth hormone' increases longevity

December 23, 2010, Saint Louis University

A compound which acts in the opposite way as growth hormone can reverse some of the signs of aging, a research team that includes a Saint Louis University physician has shown. The finding may be counter-intuitive to some older adults who take growth hormone, thinking it will help revitalize them.

Their research was published in the Dec. 6 online edition of the .

The findings are significant, says John E. Morley, M.D., study co-investigator and director of the divisions of geriatric medicine and endocrinology at Saint Louis University School of Medicine, because people sometimes take growth hormone, believing it will be the fountain of youth.

"Many older people have been taking growth hormone to rejuvenate themselves," Morley said. "These results strongly suggest that growth hormone, when given to middle aged and older people, may be hazardous."

The scientists studied the compound MZ-5-156, a "growth hormone-releasing hormone (GHRH) antagonist." They conducted their research in the SAMP8 , a strain engineered for studies of the aging process. Overall, the researchers found that MZ-5-156 had positive effects on oxidative stress in the brain, improving cognition, telomerase activity (the actions of an enzyme which protects DNA material) and , while decreasing tumor activity.

MZ-5-156, like many GHRH antagonists, inhibited several human cancers, including prostate, breast, brain and lung cancers. It also had positive effects on learning, and is linked to improvements in short-term memory. The antioxidant actions led to less oxidative stress, reversing in the aging mouse.

William A. Banks, M.D., lead study author and professor of internal medicine and geriatrics at the University of Washington School of Medicine in Seattle, said the results lead the team "to determine that antagonists of growth hormone-releasing hormone have beneficial effects on aging."

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3 comments

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mysticfree
4 / 5 (1) Dec 23, 2010
where can I get some???
danlgarmstrong
5 / 5 (1) Dec 23, 2010
where can I get some???


Make sure you really want it!
Here is some of what Wikipoedia has to say of GHRH antagonists:
GnRH antagonists competitively and reversibly bind to GnRH receptors in the pituitary gland, blocking the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. In men, the reduction in LH subsequently leads to rapid suppression of testosterone release from the testes; in women it leads to suppression of oestrogen release from the ovaries.

Unlike the GnRH agonists, which cause an initial stimulation of the hypothalamic-pituitary-gonadal axis (HPGA), leading to a surge in testosterone or oestrogen levels, GnRH antagonists have an immediate onset of action, rapidly reducing sex hormone levels without an initial surge.

Currently approved GnRH antagonists include the following:

Cetrorelix
Ganirelix
Abarelix
Degarelix
danlgarmstrong
5 / 5 (1) Dec 23, 2010
OOPS! I queried GnRH instead of GHRH!!!!

nevermind

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