Vitamin D-fortified yoghurt improves cholesterol levels and heart disease biomarkers for diabetics

November 24, 2011

People with diabetes are known to have an increased risk of heart disease. New research published in BioMed Central's open access journal BMC Medicine shows that regular consumption of a vitamin D-fortified yoghurt drink improves cholesterol levels and biomarkers of endothelial dysfunction, a precursor of heart disease, in diabetics.

Not having enough vitamin D affects the inner lining of blood vessels () eventually leading to atherosclerosis and cardiovascular disease. Endothelial dysfunction can be measured by the increased levels of a set of biomarkers, such as serum endothelin-1, E-Selectin and MMP-9. In a double-blind trial, researchers from Tehran investigated the effect of vitamin D on the glycemic status, cholesterol levels and endothelial biomarkers of diabetics. Patients were given either a plain yoghurt drink (Doogh) or the same drink fortified with vitamin D twice a day for 12 weeks.

Researchers from the National Research Institute and Faculty of Nutrition and Food Technology had previously shown that a vitamin D-fortified yoghurt drink could improve the glycemic status of people with . In collaboration with Tehran University of Medical Sciences their new trial showed that vitamin D improved the , insulin, QUICK1 (a measure of ), and found some improvement in long term HbA1c.

Dr Neyestani explained, "The patients who had taken the vitamin D yoghurt also had improved with lower total cholesterol and LDL levels and an increase in HDL. All the improvements in cholesterol seemed to be due to the reduction in insulin resistance. The biomarkers of , serum endothelin-1, E-Selectin and MMP-9, levels were also lower for the patients taking vitamin D."

Prof Djazayery continued, "Most of our patients were deficient in vitamin D at the start of the trial but the fortified yoghurt drink elevated most of their levels to normal. However, even amongst those who took the vitamin D supplement, some people (about 5%) remained deficient at the end of the 12 weeks. These people did not show the same improvements. Nevertheless for most diabetics with vitamin D deficiency this is an easy way to improve their outcome."

More information: Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: A randomized double-blind clinical trial Sakineh Shab-Bidar, Tirang R Neyestani, Abolghassem Djazayery, Mohammad-Reza Eshraghian, Anahita Houshiarrad, A'azam Gharavi, Ali Kalayi, Nastaran Shariatzadeh, Malihe Zahedirad, Niloufar Khalaji and Homa Haidari BMC Medicine (in press)

Related Stories

Recommended for you

Your pets can't put your aging on 'paws'

December 14, 2017
(HealthDay)—In a finding that's sure to ruffle some fur and feathers, scientists report that having a pet doesn't fend off age-related declines in physical or mental health.

Searching for a link between achy joints and rainy weather in a flood of data, researchers come up dry

December 13, 2017
Rainy weather has long been blamed for achy joints. Unjustly so, according to new research from Harvard Medical School. The analysis, published Dec. 13 in BMJ, found no relationship between rainfall and joint or back pain.

Mistletoe and (a large) wine: Seven-fold increase in wine glass size over 300 years

December 13, 2017
Our Georgian and Victorian ancestors probably celebrated Christmas with more modest wine consumption than we do today - if the size of their wine glasses are anything to go by. Researchers at the University of Cambridge have ...

How well can digital assistants answer questions on sex?

December 13, 2017
Google laptop searches seem to be better at finding quality online sexual health advice than digital assistants on smartphones, find experts in the Christmas issue of The BMJ.

Healthy eating linked to kids' happiness

December 13, 2017
Healthy eating is associated with better self-esteem and fewer emotional and peer problems, such as having fewer friends or being picked on or bullied, in children regardless of body weight, according to a study published ...

Owning a pet does not seem to influence signs of aging

December 13, 2017
Owning a pet does not appear to slow the rate of ageing, as measured by standard indicators, suggest the authors of a study published in the Christmas issue of The BMJ.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.