S.Africa conducts trials for shorter TB treatment

March 30, 2012

South African researchers said Friday they were conducting medical trials to shorten the duration of tuberculosis treatment to make it easier for patients to complete the full regimen.

"Fighting tuberculosis is going to require new strategies. The ongoing trial aimed at reducing the treatment period from six to four months is one of the new strategies of fighting the disease," said Gavin Churchyard, chief executive of Aurum Institute, an independent medical research body.

"South Africa has the highest burden of TB infections (in the world), therefore it is important to position ourselves in the forefront of new research to help stop the disease," he said.

The trials are conducted at the TB Research Centre, based at a public hospital in Tembisa township east of Johannesburg, one of the areas with the highest infection rates.

Aurum has also partnered with the French Sanofi to increase research capacity in various TB initiatives.

"No organisation can work alone to make a meaningful contribution towards eliminating the disease," said Christopher Viehbacher, chief executive of Sanofi.

"The long period of treatment has been identified as one of the reasons for poor adherence, resulting in drug resistant , which are more expensive to treat," he said.

This month, TB Alliance in Washington unveiled plans for the first clinical tests of a new for tuberculosis that could shorten treatment times to four months in both patients with TB and some forms of drug-resistant TB.

Many fail to complete treatment because they cannot tolerate the difficult side effects of the medications or cannot adhere to the long-term treatment, according to the TB Alliance.

This leads to drug resistant forms of the disease, or even extensively known as XDR-TB.

A total of 8.8 million people worldwide fell ill with the contagious lung disease in 2010 and around 1.4 million died, according to the (WHO).

Explore further: Trial for new drug-resistant TB treatment to begin

Related Stories

Trial for new drug-resistant TB treatment to begin

March 19, 2012
A global health alliance Monday unveiled plans for the first clinical tests of a new treatment regimen for tuberculosis, including for patients with resistance to existing multidrug programs.

Researchers validate preclinical effectiveness of TB drug target

November 29, 2011
In research at SRI International, scientists evaluating new drug targets against tuberculosis (TB) recently validated the preclinical effectiveness of a target that could rapidly eliminate infections and potentially shorten ...

Management of TB cases falls short of international standards

February 9, 2012
The management of tuberculosis cases in the European Union (EU) is not meeting international standards, according to new research.

Recommended for you

Fresh approach to tuberculosis vaccine offers better protection

January 17, 2018
A unique platform that resulted in a promising HIV vaccine has also led to a new, highly effective vaccine against tuberculosis that is moving toward testing in humans.

Study reveals how MRSA infection compromises lymphatic function

January 17, 2018
Infections of the skin or other soft tissues with the hard-to-treat MRSA (methicillin-resistant Staphylococcus aureus) bacteria appear to permanently compromise the lymphatic system, which is crucial to immune system function. ...

Newly-discovered TB blood signal provides early warning for at-risk patients

January 17, 2018
Tuberculosis can be detected in people with HIV infection via a unique blood signal before symptoms appear, according to a new study by researchers from the Crick, Imperial College London and the University of Cape Town.

New study validates clotting risk factors in chronic kidney disease

January 17, 2018
In late 2017, researchers from Boston University School of Medicine (BUSM) discovered and published (Science Translational Medicine, (9) 417, Nov 2017) a potential treatment target to prevent chronic kidney disease (CKD) ...

New study offers insights on genetic indicators of COPD risk

January 16, 2018
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk ...

Previous influenza virus exposures enhance susceptibility in another influenza pandemic

January 16, 2018
While past exposure to influenza A viruses often builds immunity to similar, and sometimes different, strains of the virus, Canadian researchers are calling for more attention to exceptions to that rule.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.