Vitamin D analogs modulate immunity in psoriasis

Vitamin D analogs modulate immunity in psoriasis
Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

(HealthDay) -- Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin (TSLP) and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

To determine whether analogs also have immune modulating effects in human psoriasis, Emi Deguchi, M.D., and colleagues from Fukuoka University in Japan, examined cytokine levels in skin biopsies from psoriatic lesions from 10 patients not treated with vitamin D3 analogs and 10 patients treated with topical vitamin D3 analogs.

The researchers found that, compared with samples from patients not treated with vitamin D3 analogs, samples from patients treated with vitamin D3 analogs had significantly higher levels of TSLP, thymus and activation-related chemokine, and C-C chemokine receptor type 4. Cathelicidin expression was also higher in these patients. Patients treated with vitamin D3 analogs had significantly lower levels of (IL)-12/IL-23 p40, IL-1α, IL-1β, and TNF-α.

"Topical vitamin D3 analogs induced TSLP and cathelicidin in psoriatic lesion, resulting in suppression of IL-12/IL-23 p40, IL-1α, IL-1β, and TNF-α, thereby ameliorating psoriatic plaque," Deguchi and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

Journal information: British Journal of Dermatology

Copyright © 2012 HealthDay. All rights reserved.

Citation: Vitamin D analogs modulate immunity in psoriasis (2012, March 9) retrieved 19 March 2024 from https://medicalxpress.com/news/2012-03-vitamin-d-analogs-modulate-immunity.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Relief from red, itchy skin: Unraveling the secrets of vitamin D

 shares

Feedback to editors