MR enterography is as good or better than standard imaging exams for pediatric Crohn's patients

April 30, 2012

MR enterography is superior to CT enterography in diagnosing fibrosis in pediatric patients with Crohn disease and equally as good as CT enterography in detecting active inflammation, and a new study shows.

The study, conducted at Massachusetts General Hospital in Boston, found that MR enterography was 77.6% accurate in depicting compared to 56.9% for CT enterography. MR enterography had an 82.1% accuracy rate versus 77.6% accuracy rate for CT enterography for detecting active inflammation, said Keith Quencer, MD, one of the authors of the study. The study included 23 with Crohn disease. All patients had both a CT enterography and MR enterography examination.

Accurately identifying fibrosis or inflammation in these patients is key to determining appropriate treatment, said Dr. Quencer. Pediatric Crohn's patients often have nonspecific symptoms. If their symptoms are due to inflammation, then is appropriate, said Dr. Quencer. On the other hand, if the symptoms are due to from fibrosis, then a surgical approach may be necessary, he said.

"While our study shows that MR enterography is as good or better than CT enterography, CT enterography is faster than MR enterography, less expensive and more widely available," Dr. Quencer said. CT enterography remains the preferred imaging modality to evaluate Crohn disease.

"We are seeing a change in our practice though," he added, "in part because MR enterography does not use radiation. "Crohn disease is a chronic disease, with patients often requiring frequent imaging studies due to symptom recurrence. As we strive to minimize , particularly in the pediatric population, MR enterography should be considered, Dr. Quencer said.

Explore further: MR enterography as effective as CT in diagnosing Crohn's disease, reduces radiation exposure

Related Stories

MR enterography as effective as CT in diagnosing Crohn's disease, reduces radiation exposure

June 15, 2011
A new study from Rhode Island Hospital has found that MR enterography (MRE) without the use of an anti-peristaltic agent were as reliable as CT enterography (CTE) in determining the presence of Crohn's disease. Additionally, ...

Imaging technology might help doctors determine best treatment for Crohn's disease patients

October 14, 2011
It's difficult for doctors to tell whether a patient with Crohn's disease has intestinal fibrosis, which requires surgery, or inflammation, which can be treated with medicine. A new imaging method might make that task easier, ...

Experts offer pointers for optimizing radiation dose in pediatric CT

January 6, 2012
An article in the January issue of the Journal of the American College of Radiology summarizes methods for radiation dose optimization in pediatric computed tomography (CT) scans. Approximately seven to eight million CT examinations ...

Experts offer pointers for optimizing radiation dose in chest CT

September 1, 2011
An article in the September issue of the Journal of the American College of Radiology summarizes methods for radiation dose optimization in chest computed tomography (CT) scans. Chest CT is the third most commonly performed ...

Recommended for you

Shooting the achilles heel of nervous system cancers

July 20, 2017
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's Norris Cotton Cancer Center ...

Molecular changes with age in normal breast tissue are linked to cancer-related changes

July 20, 2017
Several known factors are associated with a higher risk of breast cancer including increasing age, being overweight after menopause, alcohol intake, and family history. However, the underlying biologic mechanisms through ...

Immune-cell numbers predict response to combination immunotherapy in melanoma

July 20, 2017
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco ...

Discovery could lead to better results for patients undergoing radiation

July 19, 2017
More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which ...

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors

July 19, 2017
The most comprehensive analysis yet of medulloblastoma has identified genomic changes responsible for more than 75 percent of the brain tumors, including two new suspected cancer genes that were found exclusively in the least ...

Novel CRISPR-Cas9 screening enables discovery of new targets to aid cancer immunotherapy

July 19, 2017
A novel screening method developed by a team at Dana-Farber/Boston Children's Cancer and Blood Disorders Center—using CRISPR-Cas9 genome editing technology to test the function of thousands of tumor genes in mice—has ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.