Report highlights child deaths from post-surgery codeine use

April 9, 2012
Report highlights child deaths from post-Surgery codeine use

(HealthDay) -- Researchers have identified three previously unreported instances of severe opioid-induced toxicity in children following adenotonsillectomy for obstructive sleep apnea syndrome, according to a case report published online April 9 in Pediatrics.

Lauren E. Kelly, of the University of Western Ontario in London, Canada, and colleagues report three fatal or life-threatening cases of codeine-related incidents following a tonsillectomy in North American children. The children ranged from 3 to 5 years of age. Genotyping was performed to identify polymorphisms creating extensive or ultra-rapid metabolizers.

In the two fatal cases, the researchers found that functional encoding for CYP2D6 brought about a significantly greater production of potent morphine from its parent drug codeine. A severe case of respiratory depression in an extensive metabolizer was also reported.

"These cases demonstrate that analgesia with codeine or other opioids that use the CYP2D6 pathway after may not be safe in young children with obstructive sleep apnea syndrome," the authors write.

One author disclosed to Pfizer; another author disclosed serving as an expert consultant for a law firm.

Explore further: Effect of adenotonsillectomy in children with sleep-disordered breathing

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Effect of adenotonsillectomy in children with sleep-disordered breathing

December 19, 2011
Children may have a better quality of life (QOL) and diminished cardiovascular disease risk from the decreased endothelin 1 (ET-1) levels after adenotonsillectomy, according to new research published in the December 2011 ...

Intranasal corticosteroid treatment appears beneficial for children with obstructive sleep apnea

June 20, 2011
Using a fluticasone furoate nasal spray for treatment of obstructive sleep apnea in children appears to reduce production of certain inflammatory cell proteins that may play a role in development of obstructive sleep apnea, ...

Mother's postpartum oxycodone use: No safer for breastfed infants than codeine

September 6, 2011
Doctors have been prescribing codeine for postpartum pain management for many years, and, until recently, it was considered safe to breastfeed while taking the opioid. But the death of an infant exposed to codeine through ...

Recommended for you

Synthetic cannabinoid reduces sleep apnea

November 29, 2017
A synthetic version of a molecule found in the cannabis plant was safe and effective in treating obstructive sleep apnea in the first large, multi-site study of a drug for the sleep disorder funded by the National Institutes ...

Sleeping through the snoring: Researchers identify neurons that rouse the brain to breathe

November 2, 2017
A common and potentially serious sleep disorder, obstructive sleep apnea affects at least one quarter of U.S. adults and is linked to increased risk of diabetes, obesity and cardiovascular disease. In a paper published today ...

Remede system approved for sleep apnea

October 9, 2017
(HealthDay)—The Remede sleep system, an implanted device that treats central sleep apnea by activating a nerve that sends signals to the diaphragm to stimulate breathing, has been approved by the U.S. Food and Drug Administration.

Inflammation may precede sleep apnea, could be treatment target

September 1, 2017
Inflammation is traditionally thought of as a symptom of sleep apnea, but it might actually precede the disorder, potentially opening the door for new ways to treat and predict sleep apnea, according to researchers.

More evidence: Untreated sleep apnea shown to raise metabolic and cardiovascular stress

August 31, 2017
Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a new study of sleeping subjects. A report of the study's findings, published in the ...

Sleep patterns contribute to racial differences in disease risk

August 18, 2017
Poor sleep patterns could explain, in part, the differences in the risk of cardiometabolic disease between African-Americans and European-Americans, according to a new study published in Proceedings of the National Academy ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.