Metabolites linked to insulin resistance in normoglycemia

April 23, 2012
Metabolites linked to insulin resistance in normoglycemia

(HealthDay) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April 17 in Diabetes.

Peter Würtz, Ph.D., from the University of Oulu in Finland, and colleagues performed metabolic profiling using high-throughput nuclear magnetic resonance spectroscopy in 7,098 Finns (mean age, 31 years; 52 percent women).

The researchers identified 20 metabolites that were significantly associated with the homeostasis model assessment of (HOMA-IR). These included branched-chain and aromatic amino acids, intermediates in gluconeogenesis, ketone bodies, and fatty acid composition and saturation. Associations for amino acids Leu, Ile, Val, and Tyr were sex- and obesity-dependent, with significant associations only seen in abdominally obese women. Protein energy intake was associated with some (Val, Phe, Tyr, and Gln) but not with the insulin resistance index. One of 12 genetic determinants of HOMA-IR, a variant in GCKR, was significantly associated with 12 .

"Metabolic signatures extending beyond obesity and lipid abnormalities reflected the degree of insulin resistance evidenced in young, normoglycemic adults with sex-specific fingerprints," Würtz and colleagues conclude.

Explore further: Bariatric surgery more effective than dieting for glucose control

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Bariatric surgery more effective than dieting for glucose control

April 27, 2011
Researchers at Duke University Medical Center and St. Luke's and Roosevelt Hospital Center, Columbia University, have uncovered a new clue for why bariatric surgery is more effective than dietary remedies alone at controlling ...

Insulin resistance increases risk of colorectal adenomas

March 27, 2012
(HealthDay) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published ...

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

January 20, 2012
Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...

Recommended for you

Genetic discovery may help better identify children at risk for type 1 diabetes

January 17, 2018
Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating ...

Thirty-year study shows women who breastfeed for six months or more reduce their diabetes risk

January 16, 2018
In a long-term national study, breastfeeding for six months or longer cuts the risk of developing type 2 diabetes nearly in half for women throughout their childbearing years, according to new Kaiser Permanente research published ...

Women who have gestational diabetes in pregnancy are at higher risk of future health issues

January 16, 2018
Women who have gestational diabetes mellitus (GDM) during pregnancy have a higher than usual risk of developing type 2 diabetes, hypertension, and ischemic heart disease in the future, according to new research led by the ...

Diabetes gene found that causes low and high blood sugar levels in the same family

January 15, 2018
A study of families with rare blood sugar conditions has revealed a new gene thought to be critical in the regulation of insulin, the key hormone in diabetes.

Discovery could lead to new therapies for diabetics

January 12, 2018
New research by MDI Biological Laboratory scientist Sandra Rieger, Ph.D., and her team has demonstrated that an enzyme she had previously identified as playing a role in peripheral neuropathy induced by cancer chemotherapy ...

Enzyme shown to regulate inflammation and metabolism in fat tissue

January 11, 2018
The human body has two primary kinds of fat—white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.