PCB can increase risk of abdominal fat

May 29, 2012

(Medical Xpress) -- There is a correlation between high levels of the environmental toxin PCB and the distribution of body fat to the abdomen. This is shown in a new study published today in the scientific journal Obesity. Abdominal fat is already known to increase the risk of diabetes and high blood pressure, among other conditions.

Fat inside the abdomen (visceral fat) is considerably more dangerous that fat near the surface of the body (subcutaneous fat). For instance, fat in the abdomen has previously been linked to the development of diabetes. Monica Lind, associate professor in environmental medicine at the Section for Occupational and Environmental Medicine, together with Lars Lind, professor of medicine, has analysed data from the so-called PIVUS study, which comprises more than 1,000 70-year-olds in Uppsala.
 
From the same material they have previously shown that can predict the development of diabetes. In the present study, these researchers measured levels in the blood of 23 persistent organic environmental toxins in the more than 1,000 70-year-old women and men. In nearly 300 of them, with the aid of magnetic imaging, they also investigated the amount of fat in various parts of the abdomen. Previous studies have used only BMI as a measure of fatness. They found that having high levels of the highly chlorinated and very persistent compound PCB189 was related to a high proportion of fat in the .
 
"These findings may indicate that PCB189, which was also related to developing diabetes, may be of significance in how fat is stored in the body," says Monica Lind.
 
To understand the underlying mechanism, more research is needed in the form of controlled laboratory studies. According to Monica Lind, there are several possible causes. For example, it would be interesting to study whether there is a hormonal impact on fat metabolism, an inhibition of the breakdown of cortisol, or an inhibition of the creation of oestrogen.

Explore further: High levels of phthalates can lead to greater risk for type-2 diabetes

More information: Obesity (2012) doi:10.1038/oby.2012.123

Related Stories

High levels of phthalates can lead to greater risk for type-2 diabetes

April 12, 2012
There is a connection between phthalates found in cosmetics and plastics and the risk of developing diabetes among seniors. Even at a modest increase in circulating phthalate levels, the risk of diabetes is doubled. This ...

High levels of phthalates can lead to greater risk for diabetes

April 23, 2012
(Medical Xpress) -- There is a connection between phthalates found in cosmetics and plastics and the risk of developing diabetes among seniors. Even at a modest increase in circulating phthalate levels, the risk of diabetes ...

Link shown between environmental toxicants and atherosclerosis

October 11, 2011
Environmental toxicants such as dioxins, PCBs, and pesticides can pose a risk for cardiovascular disease. For the first time a link has been demonstrated between atherosclerosis and levels of long-lived organic environmental ...

Genetic study shows that low body fat may not lower risk for heart disease and diabetes

June 26, 2011
Having a lower percentage of body fat may not always lower your risk for heart disease and diabetes, according to a study by an international consortium of investigators, including two scientists from the Institute for Aging ...

Recommended for you

Link between obesity and cancer is not widely recognized

November 17, 2017
A new study published in the Journal of Public Health has shown that the majority of people in the United Kingdom do not understand the connection between weight issues and cancer. Obesity is associated with thirteen types ...

Reversing negative effects of maternal obesity

November 8, 2017
A drug that increases energy metabolism may lead to a new approach to prevent obesity in children born to overweight mothers, UNSW Sydney researchers have found.

Serving water with school lunches could prevent child, adult obesity: study

November 7, 2017
Encouraging children to drink plain water with their school lunches could prevent more than half a million youths in the U.S. from becoming overweight or obese, and trim the medical costs and indirect societal costs associated ...

Why do some obese people have 'healthier' fat tissue than others?

November 1, 2017
One little understood paradox in the study of obesity is that overweight people who break down fat at a high rate are less healthy than peers who store their fat more effectively.

Engineered protein treatment found to reduce obesity in mice, rats and primates

October 19, 2017
(Medical Xpress)—A team of researchers with pharmaceutical company Amgen Inc. report that an engineered version of a protein naturally found in the body caused test mice, rats and cynomolgus monkeys to lose weight. In their ...

Nearly 4 in 10 U.S. adults now obese (Update)

October 13, 2017
(HealthDay)—Almost forty percent adults in the United States are now obese, continuing an ever-expanding epidemic of obesity that's expected to lead to sicker Americans and higher health care costs.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.