Women have clear melanoma survival advantage over men

Women have clear melanoma survival advantage over men
Women with localized melanoma have a consistent advantage over men of approximately 30 percent for survival and progression, according to a study published online April 30 in the Journal of Clinical Oncology.
(HealthDay) -- Women with localized melanoma have a consistent advantage over men of approximately 30 percent for survival and progression, according to a study published online April 30 in the Journal of Clinical Oncology.

Arjen Joosse, M.D., from the Erasmus University Medical Center in the Netherlands, and colleagues examined the female advantage across multiple end points in four phase III randomized adjuvant treatment trials conducted by the European Organization for Research and Treatment of Cancer Melanoma Group. A total of 2,672 patients diagnosed with stage I/II melanoma were included in the analyses.

The researchers identified a consistent and independent survival advantage for in overall and disease-specific survival (adjusted hazard ratio [aHR], 0.70 and 0.74, respectively), and in time to lymph node and distant metastasis (aHR, 0.70 and 0.69, respectively). The survival advantage for female patients was consistent in both pre- and postmenopausal age groups and across all prognostic subgroups (except possibly for head and neck melanomas).

"Women have a consistent and independent relative advantage in all aspects of the progression of localized of approximately 30 percent, most likely caused by an underlying biologic sex difference," the authors write.


Explore further

Sentinel node biopsy safe, effective in head and neck melanomas

More information: doi: 10.1200/JCO.2011.38.0584
Journal information: Journal of Clinical Oncology

Copyright © 2012 HealthDay. All rights reserved.

Citation: Women have clear melanoma survival advantage over men (2012, May 1) retrieved 26 June 2019 from https://medicalxpress.com/news/2012-05-women-melanoma-survival-advantage-men.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
 shares

Feedback to editors

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more