New peri-op approach accurately IDs melanoma in nail matrix

June 14, 2012
New peri-Op approach accurately IDs melanoma in nail matrix
Intraoperative reflectance confocal microscopy can be used to diagnose melanonychia striata in the nail matrix, according to a study published online June 7 in the British Journal of Dermatology.

(HealthDay) -- Intraoperative reflectance confocal microscopy (RCM) can be used to diagnose melanonychia striata in the nail matrix, according to a study published online June 7 in the British Journal of Dermatology.

Sébastien Debarbieux, M.D., of the Centre Hospitalier Lyon Sud in Pierre Bénite, France, and colleagues assessed the feasibility of intraoperative of melanonychia striata in a series of nine patients who underwent a matricial biopsy for an acquired melanonychia (one benign lentigo, eight melanomas). RCM examination was performed in vivo and/or ex vivo.

The researchers found that confocal and histopathological features correlated well. Confocal features were used for unequivocal intraoperative diagnosis of seven of the cases, and RCM correctly classified the lentigo as benign. RCM did not provide a definite classification for the last lesion, which corresponded histopathologically to an early melanoma.

"Intraoperative RCM examination of the nail matrix is an efficient diagnostic approach of melanonychia striata that permits an extemporaneous diagnosis of malignancy and therefore a one-step surgical treatment of in situ or minimally invasive melanoma, reducing dramatically the duration of postoperative disability," the authors write.

Explore further: Melanoma screening by physicians associated with finding more cancers than patient self-detection

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Melanoma screening by physicians associated with finding more cancers than patient self-detection

July 18, 2011
Physician-based screening for melanoma is associated with higher rates of physician-detected melanoma and detection of thinner melanoma, according to a report published Online First today by Archives of Dermatology, one of ...

Recommended for you

Study: Cells of three advanced cancers die with drug-like compounds that reverse chemo failure

January 23, 2018
Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers—ovarian, prostate and breast.

'Hijacker' drives cancer in some patients with high-risk neuroblastoma

January 23, 2018
Researchers have identified mechanisms that drive about 10 percent of high-risk neuroblastoma cases and have used a new approach to show how the cancer genome "hijacks" DNA that regulates other genes. The resulting insights ...

Enzyme inhibitor combined with chemotherapy delays glioblastoma growth

January 23, 2018
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

Scientists block the siren call of two aggressive cancers

January 23, 2018
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

Researchers identify a protein that keeps metastatic breast cancer cells dormant

January 23, 2018
A study headed by ICREA researcher Roger Gomis at the Institute for Research in Biomedicine (IRB Barcelona) has identified the genes involved in the latent asymptomatic state of breast cancer metastases. The work sheds light ...

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.